Hypouricaemia and hyperuricosuria in familial renal glucosuria.
Clin Kidney J
; 6(5): 523-5, 2013 Oct.
Article
in En
| MEDLINE
| ID: mdl-26064518
ABSTRACT
Familial renal glucosuria is a rare co-dominantly inherited benign phenotype characterized by the presence of glucose in the urine. It is caused by mutations in the SLC5A2 gene that encodes SGLT2, the Na(+)-glucose cotransporter responsible for the reabsorption of the bulk of glucose in the proximal tubule. We report a case of FRG displaying both severe glucosuria and renal hypouricaemia. We hypothesize that glucosuria can disrupt urate reabsorption in the proximal tubule, directly causing hyperuricosuria.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Clin Kidney J
Year:
2013
Document type:
Article
Affiliation country: