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Methotrexate Promotes Platelet Apoptosis via JNK-Mediated Mitochondrial Damage: Alleviation by N-Acetylcysteine and N-Acetylcysteine Amide.
Paul, Manoj; Hemshekhar, Mahadevappa; Thushara, Ram M; Sundaram, Mahalingam S; NaveenKumar, Somanathapura K; Naveen, Shivanna; Devaraja, Sannaningaiah; Somyajit, Kumar; West, Robert; Nayaka, Siddaiah C; Zakai, Uzma I; Nagaraju, Ganesh; Rangappa, Kanchugarakoppal S; Kemparaju, Kempaiah; Girish, Kesturu S.
Affiliation
  • Paul M; Department of studies in Biochemistry, University of Mysore, Manasagangothri, Mysore, 570 006, India.
  • Hemshekhar M; Department of studies in Biochemistry, University of Mysore, Manasagangothri, Mysore, 570 006, India; Department of Internal Medicine, Manitoba Centre for Proteomics and Systems Biology, University of Manitoba, Winnipeg, R3E3P4, Canada.
  • Thushara RM; Department of studies in Biochemistry, University of Mysore, Manasagangothri, Mysore, 570 006, India.
  • Sundaram MS; Department of studies in Biochemistry, University of Mysore, Manasagangothri, Mysore, 570 006, India.
  • NaveenKumar SK; Department of studies in Biochemistry, University of Mysore, Manasagangothri, Mysore, 570 006, India.
  • Naveen S; Applied Nutrition Discipline, Defence Food Research Laboratory, Mysore, 570 011, India.
  • Devaraja S; Department of Studies and Research in Biochemistry, Tumkur University, Tumkur, 572 103, India.
  • Somyajit K; Department of Biochemistry, Indian Institute of Science, Bangalore, 560 012, India.
  • West R; Organosilicon Research Center, University of Wisconsin, Madison, WI, 53706-1396, United States of America.
  • Basappa; Laboratory of Chemical Biology, Department of Chemistry, Bangalore University, Bangalore, India.
  • Nayaka SC; Department of Applied Botany and Biotechnology, University of Mysore, Manasagangothri, Mysore, 570 006, India.
  • Zakai UI; Organosilicon Research Center, University of Wisconsin, Madison, WI, 53706-1396, United States of America.
  • Nagaraju G; Department of Biochemistry, Indian Institute of Science, Bangalore, 560 012, India.
  • Rangappa KS; Department of Studies in Chemistry, University of Mysore, Manasagangothri, Mysore, 570 006, India.
  • Kemparaju K; Department of studies in Biochemistry, University of Mysore, Manasagangothri, Mysore, 570 006, India.
  • Girish KS; Department of studies in Biochemistry, University of Mysore, Manasagangothri, Mysore, 570 006, India; Department of Studies and Research in Biochemistry, Tumkur University, Tumkur, 572 103, India.
PLoS One ; 10(6): e0127558, 2015.
Article in En | MEDLINE | ID: mdl-26083398
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Acetylcysteine / Methotrexate / Apoptosis / MAP Kinase Kinase 4 / Antimetabolites, Antineoplastic / Antioxidants Limits: Humans Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2015 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Acetylcysteine / Methotrexate / Apoptosis / MAP Kinase Kinase 4 / Antimetabolites, Antineoplastic / Antioxidants Limits: Humans Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2015 Document type: Article Affiliation country: Country of publication: