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Proton myo-inositol cotransporter is a novel γ-secretase associated protein that regulates Aß production without affecting Notch cleavage.
Teranishi, Yasuhiro; Inoue, Mitsuhiro; Yamamoto, Natsuko Goto; Kihara, Takahiro; Wiehager, Birgitta; Ishikawa, Taizo; Winblad, Bengt; Schedin-Weiss, Sophia; Frykman, Susanne; Tjernberg, Lars O.
Affiliation
  • Teranishi Y; Division for Neurogeriatrics, Department of NVS, Center for Alzheimer Research, Karolinska Institutet, Huddinge, Sweden.
  • Inoue M; Dainippon Sumitomo Pharma Co., Ltd, Drug Development Research Laboratories, Osaka, Japan.
  • Yamamoto NG; Division for Neurogeriatrics, Department of NVS, Center for Alzheimer Research, Karolinska Institutet, Huddinge, Sweden.
  • Kihara T; Dainippon Sumitomo Pharma Co., Ltd, Drug Development Research Laboratories, Osaka, Japan.
  • Wiehager B; Division for Neurogeriatrics, Department of NVS, Center for Alzheimer Research, Karolinska Institutet, Huddinge, Sweden.
  • Ishikawa T; Dainippon Sumitomo Pharma Co., Ltd, Drug Development Research Laboratories, Osaka, Japan.
  • Winblad B; Division for Neurogeriatrics, Department of NVS, Center for Alzheimer Research, Karolinska Institutet, Huddinge, Sweden.
  • Schedin-Weiss S; Dainippon-Sumitomo Pharma Co., Ltd, Genomic Science Laboratories, Osaka, Japan.
  • Frykman S; Division for Neurogeriatrics, Department of NVS, Center for Alzheimer Research, Karolinska Institutet, Huddinge, Sweden.
  • Tjernberg LO; Dainippon Sumitomo Pharma Co., Ltd, Innovative Drug Discovery Research Laboratories, Osaka, Japan.
FEBS J ; 282(17): 3438-51, 2015 Sep.
Article in En | MEDLINE | ID: mdl-26094765
Subject(s)
Amyloid Precursor Protein Secretases/genetics; Amyloid beta-Peptides/genetics; Glucose Transport Proteins, Facilitative/genetics; Peptide Fragments/genetics; Protons; Receptors, Notch/genetics; Adenosine Triphosphatases/antagonists & inhibitors; Adenosine Triphosphatases/genetics; Adenosine Triphosphatases/metabolism; Amyloid Precursor Protein Secretases/metabolism; Amyloid beta-Peptides/antagonists & inhibitors; Amyloid beta-Peptides/biosynthesis; Animals; Brain Chemistry; Brain-Derived Neurotrophic Factor/antagonists & inhibitors; Brain-Derived Neurotrophic Factor/genetics; Brain-Derived Neurotrophic Factor/metabolism; Carbamates/pharmacology; Dipeptides/pharmacology; Enzyme Inhibitors/pharmacology; Gene Expression Regulation; Gene Knockdown Techniques; Glucose Transport Proteins, Facilitative/antagonists & inhibitors; Glucose Transport Proteins, Facilitative/metabolism; Hippocampus/cytology; Hippocampus/drug effects; Hippocampus/metabolism; Humans; Inositol/metabolism; Mice; Microsomes/chemistry; Microsomes/drug effects; Microsomes/metabolism; Molecular Sequence Annotation; Neurons/cytology; Neurons/drug effects; Neurons/metabolism; Peptide Fragments/antagonists & inhibitors; Peptide Fragments/biosynthesis; Phospholipid Transfer Proteins/antagonists & inhibitors; Phospholipid Transfer Proteins/genetics; Phospholipid Transfer Proteins/metabolism; Primary Cell Culture; Protein Binding; Protein Stability; Proteolysis; RNA, Small Interfering/genetics; RNA, Small Interfering/metabolism; Receptors, Notch/metabolism; Signal Transduction
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptide Fragments / Protons / Amyloid beta-Peptides / Glucose Transport Proteins, Facilitative / Receptors, Notch / Amyloid Precursor Protein Secretases Type of study: Prognostic_studies / Risk_factors_studies Language: En Journal: FEBS J Journal subject: BIOQUIMICA Year: 2015 Document type: Article Affiliation country:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptide Fragments / Protons / Amyloid beta-Peptides / Glucose Transport Proteins, Facilitative / Receptors, Notch / Amyloid Precursor Protein Secretases Type of study: Prognostic_studies / Risk_factors_studies Language: En Journal: FEBS J Journal subject: BIOQUIMICA Year: 2015 Document type: Article Affiliation country: