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l-Histidyl-glycyl-glycyl-l-histidine. Amino-acid structuring of the bleomycin-type pentadentate metal-binding environment capable of efficient double-strand cleavage of plasmid DNA.
Ida, Satomi; Iwamaru, Kana; Fujita, Mikako; Okamoto, Yoshinari; Kudo, Yuri; Kurosaki, Hiromasa; Otsuka, Masami.
Affiliation
  • Ida S; Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan.
  • Iwamaru K; Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan.
  • Fujita M; School of Pharmacy, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan.
  • Okamoto Y; Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan.
  • Kudo Y; Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan.
  • Kurosaki H; Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan.
  • Otsuka M; Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan. Electronic address: motsuka@gpo.kumamoto-u.ac.jp.
Bioorg Chem ; 62: 8-14, 2015 Oct.
Article in En | MEDLINE | ID: mdl-26159895
A tetrapeptide, l-histidyl-glycyl-glycyl-l-histidine (HGGH), was synthesized and the pUC19 plasmid DNA cleaving activity by copper(II) complex of HGGH (Cu(II)-HGGH) was investigated. Cu(II)-HGGH showed bleomycin-like DNA cleaving activity and, at 50nM, converted a supercoiled DNA efficiently to a linear DNA in the presence of 500µM H2O2/sodium ascorbate through an oxidative pathway.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oligopeptides / Copper / DNA Cleavage / Coordination Complexes Language: En Journal: Bioorg Chem Year: 2015 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oligopeptides / Copper / DNA Cleavage / Coordination Complexes Language: En Journal: Bioorg Chem Year: 2015 Document type: Article Affiliation country: Country of publication: