Investigation of ectopic recurrent skull base and cervical chordomas: The Institut Curie's proton therapy center experience.
Head Neck
; 38 Suppl 1: E1238-46, 2016 04.
Article
in En
| MEDLINE
| ID: mdl-26339866
ABSTRACT
BACKGROUND:
Cervical and skull base chordomas may relapse locally, marginally, or in ectopic sites (ie, surgical pathway, lymph nodes, prevertebral space, subdural space, or distant organs).METHODS:
Among 371 patients treated between 1995 and 2010, we matched the initial dosimetry with the 3D imaging of recurrence and selected the patients with isolated ectopic recurrence.RESULTS:
During our follow-up, we identified 13 patients who developed ectopic relapses (n = 18) in the form of lung metastasis (n = 2), axial dissemination (n = 6), nodal recurrence (n = 2), subcutaneous metastasis (n = 3), and/or seeding along the surgical pathway (n = 5). Despite treatment of these 13 patients with radiation, surgical interventions, and/or chemotherapy, we could only salvage 5 patients with recurrence in surgical pathway, whereas the remaining 8 patients succumbed to a poor prognosis.CONCLUSION:
Our study emphasizes an urgent need for prediction and early diagnosis of ectopic relapses in patients with cervical and skull base chordoma to improve accuracy of their aggressive treatments. © 2015 Wiley Periodicals, Inc. Head Neck 38 E1238-E1246, 2016.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Chordoma
/
Skull Base Neoplasms
/
Neoplasm Recurrence, Local
Type of study:
Observational_studies
/
Risk_factors_studies
/
Screening_studies
Limits:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Head Neck
Journal subject:
NEOPLASIAS
Year:
2016
Document type:
Article
Affiliation country: