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Inhibition of NAADP signalling on reperfusion protects the heart by preventing lethal calcium oscillations via two-pore channel 1 and opening of the mitochondrial permeability transition pore.
Davidson, Sean M; Foote, Kirsty; Kunuthur, Suma; Gosain, Raj; Tan, Noah; Tyser, Richard; Zhao, Yong Juan; Graeff, Richard; Ganesan, A; Duchen, Michael R; Patel, Sandip; Yellon, Derek M.
Affiliation
  • Davidson SM; The Hatter Cardiovascular Institute, University College London, 67 Chenies Mews, WC1E 6HX London, UK s.davidson@ucl.ac.uk.
  • Foote K; The Hatter Cardiovascular Institute, University College London, 67 Chenies Mews, WC1E 6HX London, UK.
  • Kunuthur S; The Hatter Cardiovascular Institute, University College London, 67 Chenies Mews, WC1E 6HX London, UK.
  • Gosain R; School of Chemistry, University of Southampton, Highfield, Southampton, UK.
  • Tan N; The Hatter Cardiovascular Institute, University College London, 67 Chenies Mews, WC1E 6HX London, UK.
  • Tyser R; The Hatter Cardiovascular Institute, University College London, 67 Chenies Mews, WC1E 6HX London, UK.
  • Zhao YJ; Department of Physiology, Li Ka Shing School of Medicine, The University of Hong Kong, Hong Kong, China.
  • Graeff R; Department of Physiology, Li Ka Shing School of Medicine, The University of Hong Kong, Hong Kong, China.
  • Ganesan A; School of Pharmacy, University of East Anglia, Norwich, UK.
  • Duchen MR; Department of Cell and Developmental Biology, University College London, London, UK.
  • Patel S; Department of Cell and Developmental Biology, University College London, London, UK.
  • Yellon DM; The Hatter Cardiovascular Institute, University College London, 67 Chenies Mews, WC1E 6HX London, UK.
Cardiovasc Res ; 108(3): 357-66, 2015 Dec 01.
Article in En | MEDLINE | ID: mdl-26395965
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Piperazines / Carbolines / Calcium Channels / Myocardial Reperfusion Injury / Calcium Signaling / Myocytes, Cardiac / Mitochondrial Membrane Transport Proteins / Mitochondria, Heart / Myocardial Infarction / NADP Type of study: Prognostic_studies Limits: Animals Language: En Journal: Cardiovasc Res Year: 2015 Document type: Article Affiliation country:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Piperazines / Carbolines / Calcium Channels / Myocardial Reperfusion Injury / Calcium Signaling / Myocytes, Cardiac / Mitochondrial Membrane Transport Proteins / Mitochondria, Heart / Myocardial Infarction / NADP Type of study: Prognostic_studies Limits: Animals Language: En Journal: Cardiovasc Res Year: 2015 Document type: Article Affiliation country: