When do patients prefer a direct oral anticoagulant over a vitamin K antagonist?
Neth J Med
; 73(8): 368-72, 2015 Oct.
Article
in En
| MEDLINE
| ID: mdl-26478546
ABSTRACT
BACKGROUND:
The reasons for patients to change their usual vitamin K antagonist (VKA) treatment to a direct oral anticoagulant (DOAC) are unexplored.METHOD:
A random sample of 200 patients treated with VKAs for the indication of atrial fibrillation from the Thrombosis Service in Amsterdam was selected. A survey, using the treatment trade-off technique, was sent to participants. The trade-off included four scenarios 1 (no need for laboratory controls); 2 (less bleeding); 3 (less interactions); 4 (more effective).RESULTS:
Under scenario 1, 57% of the patients would have made the switch, with a further increase to 65% with scenario 2 (trend value, p = 0.006, 95% CI 1.11-1.85). In addition, in each scenario patients who were less satisfied with their current treatment were more likely to switch to a DOAC compared with satisfied patients. The variables duration of treatment, gender, age and educational level did not affect the preference for a DOAC.CONCLUSION:
Patients considered no requirement for regular laboratory control and a lower risk of bleeding the most important arguments to switch to a DOAC.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Vitamin K
/
Patient Preference
/
Drug Substitution
/
Factor Xa Inhibitors
/
Anticoagulants
Limits:
Aged
/
Aged80
/
Female
/
Humans
/
Male
Language:
En
Journal:
Neth J Med
Year:
2015
Document type:
Article
Affiliation country: