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E-CADHERIN CODING GENE (CDH1) AND NONSYNDROMIC CLEFT LIP WITH OR WITHOUT CLEFT PALATE: IS THERE ANY ASSOCIATION?
Girardi, A; Scapoli, L; Cura, F; Palmieri, A; Carinci, F; Morselli, P G; Spinelli, G; Caramelli, E; Martinelli, M.
Affiliation
  • Girardi A; Department of Experimental, Diagnostic and Speciality Medicine, University of Bologna, Bologna, Italy.
  • Scapoli L; Department of Experimental, Diagnostic and Speciality Medicine, University of Bologna, Bologna, Italy.
  • Cura F; Department of Experimental, Diagnostic and Speciality Medicine, University of Bologna, Bologna, Italy.
  • Palmieri A; Department of Experimental, Diagnostic and Speciality Medicine, University of Bologna, Bologna, Italy.
  • Carinci F; Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy.
  • Morselli PG; Department of Experimental, Diagnostic and Speciality Medicine, University of Bologna, Bologna, Italy; Plastic Surgery Unit, Sant’Orsola Malpighi University Hospital, Bologna, Italy.
  • Spinelli G; Maxillo-Facial Surgery Unit, Careggi Hospital, Firenze, Italy.
  • Caramelli E; Department of Experimental, Diagnostic and Speciality Medicine, University of Bologna, Bologna, Italy.
  • Martinelli M; Department of Experimental, Diagnostic and Speciality Medicine, University of Bologna, Bologna, Italy.
J Biol Regul Homeost Agents ; 29(3 Suppl 1): 117-22, 2015.
Article in En | MEDLINE | ID: mdl-26511190
ABSTRACT
Epithelial to Mesenchymal Transition (EMT) is an important process involved in cancer, embryogenesis and organ development. Its role in nonsyndromic cleft lip with or without cleft palate (NSCL/P) has been extensively investigated and successfully linked to the disease. In this study, we focused on a gene, CDH1, encoding for E-cadherin, a key protein in EMT. We carried out an association study on an Italian sample group, genotyping four single nucleotide variations within the CDH1 gene, in order to verify the potential role of this gene in NSCL/P etiology. Neither the haplotype nor the family-based association test revealed any association between the genotyped SNPs and the pathology. Our results demonstrate that, in our Italian sample study, the analyzed single nucleotide polymorphisms are not associated to NSCL/P.
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Collection: 01-internacional Database: MEDLINE Type of study: Risk_factors_studies Language: En Journal: J Biol Regul Homeost Agents Journal subject: BIOLOGIA / BIOQUIMICA Year: 2015 Document type: Article Affiliation country:
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Collection: 01-internacional Database: MEDLINE Type of study: Risk_factors_studies Language: En Journal: J Biol Regul Homeost Agents Journal subject: BIOLOGIA / BIOQUIMICA Year: 2015 Document type: Article Affiliation country: