Shedding of Rubella Virus among Infants with Congenital Rubella Syndrome Born in Tokyo, Japan, 2013-2014.
Jpn J Infect Dis
; 69(5): 418-23, 2016 Sep 21.
Article
in En
| MEDLINE
| ID: mdl-26567831
ABSTRACT
Rubella is usually a mild illness, with febrile rash being its main symptom. However, serious consequences of rubella infection can result when the infection occurs during the early stages of pregnancy. After the occurrence of a rubella outbreak in Japan that was observed from 2012 to 2013, 45 infants were reportedly born with congenital rubella syndrome (CRS). We prospectively followed the 15 CRS cases reported in Tokyo to determine the virus shedding periods by using nested reverse transcriptase-polymerase chain reaction to detect rubella virus genes. Throast swabs were used for virus detection. The virus shedding period was measured from birth until the time when the sample last tested positive followed by 2 consecutive negative samples. Kaplan-Meier method was used to estimate the proportion of cases remaining positive for rubella virus genes over time. The proportion of CRS cases shedding virus dropped steadily after birth, dropping to 33.8% at 6 months and 16.9% at 12 months. Our findings also suggested that the earlier the mother's onset of rubella during pregnancy, the longer the infant remained positive. Based on our findings, we believe that infants with CRS should be monitored for rubella virus shedding until 1 year of age.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Rubella virus
/
Rubella Syndrome, Congenital
/
Virus Shedding
Type of study:
Observational_studies
Limits:
Female
/
Humans
/
Infant
/
Male
/
Newborn
/
Pregnancy
Country/Region as subject:
Asia
Language:
En
Journal:
Jpn J Infect Dis
Journal subject:
DOENCAS TRANSMISSIVEIS
Year:
2016
Document type:
Article
Publication country:
JAPAN
/
JAPON
/
JAPÃO
/
JP