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Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma.
Tardito, Saverio; Oudin, Anaïs; Ahmed, Shafiq U; Fack, Fred; Keunen, Olivier; Zheng, Liang; Miletic, Hrvoje; Sakariassen, Per Øystein; Weinstock, Adam; Wagner, Allon; Lindsay, Susan L; Hock, Andreas K; Barnett, Susan C; Ruppin, Eytan; Mørkve, Svein Harald; Lund-Johansen, Morten; Chalmers, Anthony J; Bjerkvig, Rolf; Niclou, Simone P; Gottlieb, Eyal.
Affiliation
  • Tardito S; Cancer Metabolism Research Unit, Cancer Research UK, Beatson Institute, Switchback Road, Glasgow G61 1BD, UK.
  • Oudin A; NorLux Neuro-Oncology Laboratory, Department of Oncology, Luxembourg Institute of Health, L-1526 Luxembourg, Luxembourg.
  • Ahmed SU; Institute of Cancer Sciences, University of Glasgow, Glasgow G12 8QQ, UK.
  • Fack F; NorLux Neuro-Oncology Laboratory, Department of Oncology, Luxembourg Institute of Health, L-1526 Luxembourg, Luxembourg.
  • Keunen O; NorLux Neuro-Oncology Laboratory, Department of Oncology, Luxembourg Institute of Health, L-1526 Luxembourg, Luxembourg.
  • Zheng L; Cancer Metabolism Research Unit, Cancer Research UK, Beatson Institute, Switchback Road, Glasgow G61 1BD, UK.
  • Miletic H; Kristian Gerhard Jebsen Brain Tumour Research Center, Department of Biomedicine, University of Bergen, Bergen N-5009, Norway.
  • Sakariassen PØ; Kristian Gerhard Jebsen Brain Tumour Research Center, Department of Biomedicine, University of Bergen, Bergen N-5009, Norway.
  • Weinstock A; The Blavatnik School of Computer Science, Tel Aviv University, Tel Aviv 69978, Israel.
  • Wagner A; The Blavatnik School of Computer Science, Tel Aviv University, Tel Aviv 69978, Israel.
  • Lindsay SL; Institute of Infection, Immunity and inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK.
  • Hock AK; Cancer Metabolism Research Unit, Cancer Research UK, Beatson Institute, Switchback Road, Glasgow G61 1BD, UK.
  • Barnett SC; Institute of Infection, Immunity and inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK.
  • Ruppin E; The Blavatnik School of Computer Science, Tel Aviv University, Tel Aviv 69978, Israel.
  • Mørkve SH; The Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.
  • Lund-Johansen M; Department of Neurosurgery, Haukeland University Hospital, Bergen N-5021, Norway.
  • Chalmers AJ; Department of Neurosurgery, Haukeland University Hospital, Bergen N-5021, Norway.
  • Bjerkvig R; Department of Clinical Medicine, University of Bergen, Bergen N-5020, Norway.
  • Niclou SP; Institute of Cancer Sciences, University of Glasgow, Glasgow G12 8QQ, UK.
  • Gottlieb E; NorLux Neuro-Oncology Laboratory, Department of Oncology, Luxembourg Institute of Health, L-1526 Luxembourg, Luxembourg.
Nat Cell Biol ; 17(12): 1556-68, 2015 Dec.
Article in En | MEDLINE | ID: mdl-26595383
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain Neoplasms / Glioblastoma / Cell Proliferation / Glutamine / Glutamate-Ammonia Ligase / Nucleotides Limits: Animals / Female / Humans / Male Language: En Journal: Nat Cell Biol Year: 2015 Document type: Article Affiliation country:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain Neoplasms / Glioblastoma / Cell Proliferation / Glutamine / Glutamate-Ammonia Ligase / Nucleotides Limits: Animals / Female / Humans / Male Language: En Journal: Nat Cell Biol Year: 2015 Document type: Article Affiliation country: