Interferon but not MxB inhibits foamy retroviruses.
Virology
; 488: 51-60, 2016 Jan 15.
Article
in En
| MEDLINE
| ID: mdl-26609934
ABSTRACT
Foamy viruses (FV) are retroviruses that are widely distributed in primate and non-primate animal species. We tested here FV with capsids of simian and non-simian origin for sensitivity to interferon-ß (IFN-ß). Our data show significant inhibition of FV by IFN-ß early in infection of human HOS and THP-1 but not of HEK293T cells. The post-entry restriction of FV was not mediated by the interferon-induced MxB protein that was recently identified as a capsid-interacting restriction factor targeting Human immunodeficiency virus (HIV) before integration. Neither the ectopic expression of MxA or MxB in HEK293T cells nor the lack of MxB expression in CRISPR/CAS MxB THP-1 knockout cells impacted the infection of the tested FV. IFN-ß treated THP-1 and THP-1 KO MxB cells showed the same extend of restriction to FV. Together, the data demonstrate that IFN-ß inhibits FV early in infection and that MxB is not a restriction factor of FV.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Interferon-beta
/
Spumavirus
/
Myxovirus Resistance Proteins
Type of study:
Prognostic_studies
Limits:
Humans
Language:
En
Journal:
Virology
Year:
2016
Document type:
Article
Affiliation country: