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Reversion to an embryonic alternative splicing program enhances leukemia stem cell self-renewal.
Holm, Frida; Hellqvist, Eva; Mason, Cayla N; Ali, Shawn A; Delos-Santos, Nathaniel; Barrett, Christian L; Chun, Hye-Jung; Minden, Mark D; Moore, Richard A; Marra, Marco A; Runza, Valeria; Frazer, Kelly A; Sadarangani, Anil; Jamieson, Catriona H M.
Affiliation
  • Holm F; Division of Regenerative Medicine, Department of Medicine, Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093-0820;
  • Hellqvist E; Division of Regenerative Medicine, Department of Medicine, Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093-0820;
  • Mason CN; Division of Regenerative Medicine, Department of Medicine, Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093-0820;
  • Ali SA; Division of Regenerative Medicine, Department of Medicine, Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093-0820;
  • Delos-Santos N; Division of Regenerative Medicine, Department of Medicine, Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093-0820;
  • Barrett CL; Institute of Genomic Medicine, Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093;
  • Chun HJ; Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia, V5Z 1L3, Canada;
  • Minden MD; Division of Hematology, Princess Margaret Hospital, Toronto, Ontario, M5G 2M9, Canada;
  • Moore RA; Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia, V5Z 1L3, Canada;
  • Marra MA; Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia, V5Z 1L3, Canada;
  • Runza V; Roche Innovation Center Penzberg, Oncology Division, Roche Pharmaceutical Research and Early Development, 82377 Penzberg, Germany.
  • Frazer KA; Institute of Genomic Medicine, Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093;
  • Sadarangani A; Division of Regenerative Medicine, Department of Medicine, Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093-0820;
  • Jamieson CH; Division of Regenerative Medicine, Department of Medicine, Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093-0820; cjamieson@ucsd.edu.
Proc Natl Acad Sci U S A ; 112(50): 15444-9, 2015 Dec 15.
Article in En | MEDLINE | ID: mdl-26621726
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Alternative Splicing / Human Embryonic Stem Cells / Cell Self Renewal Limits: Adult / Animals / Female / Humans / Male / Middle aged Language: En Journal: Proc Natl Acad Sci U S A Year: 2015 Document type: Article Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Alternative Splicing / Human Embryonic Stem Cells / Cell Self Renewal Limits: Adult / Animals / Female / Humans / Male / Middle aged Language: En Journal: Proc Natl Acad Sci U S A Year: 2015 Document type: Article Country of publication: