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The Effects of the Organic Flame-Retardant 1,2-Dibromo-4-(1,2-dibromoethyl) Cyclohexane (TBECH) on Androgen Signaling in Human Prostate Cancer Cell Lines.
Wong, Lilian I L; Reers, Alexandra R; Currier, Heidi A; Williams, Tony D; Cox, Michael E; Elliott, John E; Beischlag, Timothy V.
Affiliation
  • Wong LI; Department of Biological Sciences, Simon Fraser University, Burnaby, B.C. V5A 1S6, Canada.
  • Reers AR; Department of Biological Sciences, Simon Fraser University, Burnaby, B.C. V5A 1S6, Canada.
  • Currier HA; Department of Biological Sciences, Simon Fraser University, Burnaby, B.C. V5A 1S6, Canada.
  • Williams TD; Department of Biological Sciences, Simon Fraser University, Burnaby, B.C. V5A 1S6, Canada.
  • Cox ME; The Vancouver Prostate Centre, Vancouver Coastal Health Research Institute, Vancouver, B.C. V6H 3Z6, Canada.
  • Elliott JE; Pacific Wildlife Research Center, Environment Canada, Delta, B.C. V4K 3N2, Canada.
  • Beischlag TV; Faculty of Health Sciences, Simon Fraser University, Burnaby, B.C. V5A 1S6, Canada. tvb@sfu.ca.
J Biochem Mol Toxicol ; 30(5): 239-42, 2016 May.
Article in En | MEDLINE | ID: mdl-26729308
ABSTRACT
The effects of the organic flame retardant 1,2-Dibromo-4-(1,2-dibromoethyl) cyclohexane (TBECH) on androgen receptor target gene expression were examined in the human LNCaP prostate cancer cell line. While γ-/δ-TBECH alone led to a significant increase in prostate-specific antigen (PSA) mRNA accumulation, both the α-/-TBECH and γ-/δ-TBECH mixtures repressed androgen-inducible PSA mRNA and protein accumulation in human LNCaP cells. Thus, we hypothesize that isomeric mixtures of TBECH may act as partial agonists of the androgen receptor.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Receptors, Androgen / Cyclohexanes / Environmental Pollutants / Epithelial Cells / Endocrine Disruptors / Flame Retardants Limits: Humans / Male Language: En Journal: J Biochem Mol Toxicol Journal subject: BIOLOGIA MOLECULAR / BIOQUIMICA / TOXICOLOGIA Year: 2016 Document type: Article Affiliation country:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Receptors, Androgen / Cyclohexanes / Environmental Pollutants / Epithelial Cells / Endocrine Disruptors / Flame Retardants Limits: Humans / Male Language: En Journal: J Biochem Mol Toxicol Journal subject: BIOLOGIA MOLECULAR / BIOQUIMICA / TOXICOLOGIA Year: 2016 Document type: Article Affiliation country: