Physical Activity and the Risk of Primary Hyperparathyroidism.
J Clin Endocrinol Metab
; 101(4): 1590-7, 2016 04.
Article
in En
| MEDLINE
| ID: mdl-26812691
ABSTRACT
CONTEXT Primary hyperparathyroidism (P-HPTH) is relatively common and predominantly affects women. Prior studies have shown that physical activity (PA) can lower PTH levels. OBJECTIVE:
Our objective was to evaluate the hypothesis that lower PA is a risk factor for developing P-HPTH. DESIGN, SETTING, ANDPARTICIPANTS:
This prospective cohort study included 69 621 female participants in the Nurses' Health Study I followed for 22 years. EXPOSURES PA and other dietary and demographic exposures were quantified via detailed, and validated, biennial questionnaires.OUTCOMES:
Incident P-HPTH was confirmed by medical record review after initial assessment by questionnaire. Adjusted Cox proportional hazards models were used to evaluate whether PA was an independent risk factor for developing P-HPTH. We also evaluated the risk of developing P-HPTH when combining low PA (<16 metabolic equivalent hours/week) with a previously identified independent risk factor for developing P-HPTH low calcium intake (<800 mg/day). The relation between PA and PTH levels was evaluated in 625 participants.RESULTS:
We confirmed 302 incident cases of P-HPTH during 1 474 993 person-years of follow-up. Participants in the highest quintile (Q) of PA had a 50% lower risk of developing P-HPTH age-adjusted relative risks and 95% confidence intervals for incident P-HPTH by lowest to highest of PA were Q1 = 1.0 (reference); Q2 = 0.83 (0.601.15); Q3 = 0.84 (0.611.15); Q4 = 0.50 (0.340.74); Q5 = 0.50 (0.350.73); P for trend <.001. Extensive multivariable adjustments did not materially change these findings. The adjusted relative risk for developing P-HPTH among participants with the combination lower PA and lower calcium intake was 2.37-fold (1.603.51) higher than in participants with higher PA and higher calcium intake. PA was inversely correlated with serum PTH (ρ = −0.09, P = .03); the mean adjusted serum PTH in Q 25 of PA was lower than in Q 1 (36.3 vs 39.1 pg/mL, P = .02).CONCLUSION:
Low physical activity may be a modifiable risk factor for developing P-HPTH in women.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Exercise
/
Hyperparathyroidism, Primary
Type of study:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adult
/
Female
/
Humans
/
Middle aged
Country/Region as subject:
America do norte
Language:
En
Journal:
J Clin Endocrinol Metab
Year:
2016
Document type:
Article