[Evaluation of the correlation between IL-1ß, IL-8, IFN-γ cytokine concentration in cervico-vaginal fluid and the risk of preterm delivery]. / Ocena korelacji miedzy stezeniem cytokin IL-1ß, IL-8, IFN-ß w wydzielinie szyjkowo-pochwowej, a ryzykiem wystapienia porodu przedwczesnego.
Ginekol Pol
; 86(11): 821-6, 2015 Nov.
Article
in Pl
| MEDLINE
| ID: mdl-26817313
ABSTRACT
OBJECTIVES:
The aim of the study was to evaluate IL-1ß, II-8, IFN-γ cytokine concentrations in cervico-vaginal fluid in patients with threatening preterm delivery. MATERIAL ANDMETHODS:
The study group included 84 patients between 27 and 34 weeks of pregnancy admitted with symptoms of threatened preterm delivery. The cervico-vaginal fluid was taken from each patient qualified for the study and IL-1ß, II-8, IFN-γ concentration was analyzed by enzyme-linked immunosorbent assay (ELISA). The following factors were analyzed maternal age and parity gestational age at admission for the examination and at delivery, sex of the newborn, Apgar evaluation at 1 and 5 minutes of life, umbilical blood pH, history of miscarriage or preterm delivery pre-pregnancy body mass index, and smoking. Their influence on the concentration of biochemical markers tested in patients at risk of preterm delivery was investigated.RESULTS:
In the study group, patients who delivered preterm had significantly higher concentrations of IL-1ß and II-8 as compared to patients who delivered at term. Patients who delivered preterm more often had a history of a miscarriage and their newborns had lower birth weight, lower Apgar score, and lower pH of the umbilical blood.CONCLUSION:
As far as factors significantly influencing cytokine concentrations are concerned, the level of IL-1ß and II-8 concentration is an independent predictor of preterm delivery in patients with threatened preterm labor. In the study group, the IFN-γ concentration did not significantly diversify patients who delivered preterm and at term.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Vagina
/
Interleukin-8
/
Interferon-gamma
/
Interleukin-1
/
Obstetric Labor, Premature
Type of study:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Female
/
Humans
/
Pregnancy
Language:
Pl
Journal:
Ginekol Pol
Year:
2015
Document type:
Article