Infrequent ras activation in chronic myelogenous leukemia (CML): activating 61st codon mutation in the CML-derived cell line, IM-9.
Leukemia
; 3(11): 827-9, 1989 Nov.
Article
in En
| MEDLINE
| ID: mdl-2682048
ABSTRACT
The proto-oncogene c-N-ras frequently bears point mutations in ANLL cell DNA which endow it with the capacity to transform NIH/3T3 cells in vitro. Chronic myelogenous leukemia (CML) is a neoplasm highly related to ANLL since it involves the same hematopoietic progenitor cells and ultimately transforms to a neoplasm virtually indistinguishable from acute nonlymphoblastic leukemia (ANLL). Thus, we and others have examined ras genes in CML. This report confirms that ras gene activation is a very infrequent event in CML. However, a lymphoblastic cell line derived from a patient with CML did exhibit a novel second exon 61st codon activating mutation of c-N-ras.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Codon
/
RNA, Messenger
/
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
/
Gene Expression Regulation
/
Genes, ras
/
Mutation
Limits:
Humans
Language:
En
Journal:
Leukemia
Journal subject:
HEMATOLOGIA
/
NEOPLASIAS
Year:
1989
Document type:
Article