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Synthesis and SAR assessment of novel Tubathian analogs in the pursuit of potent and selective HDAC6 inhibitors.
De Vreese, Rob; Depetter, Yves; Verhaeghe, Tom; Desmet, Tom; Benoy, Veronick; Haeck, Wanda; Van Den Bosch, Ludo; D'hooghe, Matthias.
Affiliation
  • De Vreese R; SynBioC Research Group, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B-9000 Ghent, Belgium. matthias.dhooghe@UGent.be.
  • Depetter Y; SynBioC Research Group, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B-9000 Ghent, Belgium. matthias.dhooghe@UGent.be.
  • Verhaeghe T; Centre for Industrial Biotechnology and Biocatalysis, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B-9000 Ghent, Belgium.
  • Desmet T; Centre for Industrial Biotechnology and Biocatalysis, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B-9000 Ghent, Belgium.
  • Benoy V; Laboratory of Neurobiology and Vesalius Research Center (VIB), Research Institute for Neuroscience and Disease (LIND), KU Leuven, Belgium.
  • Haeck W; Laboratory of Neurobiology and Vesalius Research Center (VIB), Research Institute for Neuroscience and Disease (LIND), KU Leuven, Belgium.
  • Van Den Bosch L; Laboratory of Neurobiology and Vesalius Research Center (VIB), Research Institute for Neuroscience and Disease (LIND), KU Leuven, Belgium.
  • D'hooghe M; SynBioC Research Group, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B-9000 Ghent, Belgium. matthias.dhooghe@UGent.be.
Org Biomol Chem ; 14(8): 2537-49, 2016 Feb 28.
Article in En | MEDLINE | ID: mdl-26822143
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Histone Deacetylase Inhibitors / Histone Deacetylases / Hydroxamic Acids / Indoles Limits: Humans Language: En Journal: Org Biomol Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2016 Document type: Article Affiliation country:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Histone Deacetylase Inhibitors / Histone Deacetylases / Hydroxamic Acids / Indoles Limits: Humans Language: En Journal: Org Biomol Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2016 Document type: Article Affiliation country: