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The genomic basis of parasitism in the Strongyloides clade of nematodes.
Hunt, Vicky L; Tsai, Isheng J; Coghlan, Avril; Reid, Adam J; Holroyd, Nancy; Foth, Bernardo J; Tracey, Alan; Cotton, James A; Stanley, Eleanor J; Beasley, Helen; Bennett, Hayley M; Brooks, Karen; Harsha, Bhavana; Kajitani, Rei; Kulkarni, Arpita; Harbecke, Dorothee; Nagayasu, Eiji; Nichol, Sarah; Ogura, Yoshitoshi; Quail, Michael A; Randle, Nadine; Xia, Dong; Brattig, Norbert W; Soblik, Hanns; Ribeiro, Diogo M; Sanchez-Flores, Alejandro; Hayashi, Tetsuya; Itoh, Takehiko; Denver, Dee R; Grant, Warwick; Stoltzfus, Jonathan D; Lok, James B; Murayama, Haruhiko; Wastling, Jonathan; Streit, Adrian; Kikuchi, Taisei; Viney, Mark; Berriman, Matthew.
Affiliation
  • Hunt VL; School of Biological Sciences, University of Bristol, Bristol, UK.
  • Tsai IJ; Biodiversity Research Center, Academia Sinica, Taipei, Taiwan.
  • Coghlan A; Division of Parasitology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
  • Reid AJ; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK.
  • Holroyd N; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK.
  • Foth BJ; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK.
  • Tracey A; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK.
  • Cotton JA; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK.
  • Stanley EJ; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK.
  • Beasley H; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK.
  • Bennett HM; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK.
  • Brooks K; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK.
  • Harsha B; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK.
  • Kajitani R; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK.
  • Kulkarni A; Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Meguro-ku, Tokyo, Japan.
  • Harbecke D; Max Planck Institute for Developmental Biology, Tübingen, Germany.
  • Nagayasu E; Max Planck Institute for Developmental Biology, Tübingen, Germany.
  • Nichol S; Division of Parasitology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
  • Ogura Y; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK.
  • Quail MA; Department of Bacteriology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan.
  • Randle N; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK.
  • Xia D; Department of Infection Biology, Institute of Infection and Global Health and School of Veterinary Science, University of Liverpool, Liverpool, UK.
  • Brattig NW; Department of Infection Biology, Institute of Infection and Global Health and School of Veterinary Science, University of Liverpool, Liverpool, UK.
  • Soblik H; Department of Molecular Medicine, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
  • Ribeiro DM; Department of Molecular Medicine, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
  • Sanchez-Flores A; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK.
  • Hayashi T; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK.
  • Itoh T; Unidad de Secuenciación Masiva y Bioinformática, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, Mexico.
  • Denver DR; Department of Bacteriology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan.
  • Grant W; Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Meguro-ku, Tokyo, Japan.
  • Stoltzfus JD; Department of Intergrative Biology, Oregon State University, Corvallis, Oregon, USA.
  • Lok JB; Department of Animal, Plant and Soil Sciences, La Trobe University, Melbourne, Victoria, Australia.
  • Murayama H; Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Wastling J; Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Streit A; Division of Parasitology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
  • Kikuchi T; Department of Infection Biology, Institute of Infection and Global Health and School of Veterinary Science, University of Liverpool, Liverpool, UK.
  • Viney M; Faculty of Natural Sciences, University of Keele, Keele, UK.
  • Berriman M; Max Planck Institute for Developmental Biology, Tübingen, Germany.
Nat Genet ; 48(3): 299-307, 2016 Mar.
Article in En | MEDLINE | ID: mdl-26829753
ABSTRACT
Soil-transmitted nematodes, including the Strongyloides genus, cause one of the most prevalent neglected tropical diseases. Here we compare the genomes of four Strongyloides species, including the human pathogen Strongyloides stercoralis, and their close relatives that are facultatively parasitic (Parastrongyloides trichosuri) and free-living (Rhabditophanes sp. KR3021). A significant paralogous expansion of key gene families--families encoding astacin-like and SCP/TAPS proteins--is associated with the evolution of parasitism in this clade. Exploiting the unique Strongyloides life cycle, we compare the transcriptomes of the parasitic and free-living stages and find that these same gene families are upregulated in the parasitic stages, underscoring their role in nematode parasitism.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Strongyloides / Strongyloidiasis / Symbiosis / Genomics Limits: Animals / Humans Language: En Journal: Nat Genet Journal subject: GENETICA MEDICA Year: 2016 Document type: Article Affiliation country:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Strongyloides / Strongyloidiasis / Symbiosis / Genomics Limits: Animals / Humans Language: En Journal: Nat Genet Journal subject: GENETICA MEDICA Year: 2016 Document type: Article Affiliation country: