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Preclinical and first-in-human phase I studies of KW-2450, an oral tyrosine kinase inhibitor with insulin-like growth factor receptor-1/insulin receptor selectivity.
Schwartz, Gary K; Dickson, Mark A; LoRusso, Patricia M; Sausville, Edward A; Maekawa, Yoshimi; Watanabe, Yasuo; Kashima, Naomi; Nakashima, Daisuke; Akinaga, Shiro.
Affiliation
  • Schwartz GK; Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, USA, USA.
  • Dickson MA; Memorial Sloan-Kettering Cancer Center, New York, NY, USA, USA.
  • LoRusso PM; Weill Cornell Medical College, New York, NY, USA, USA.
  • Sausville EA; Yale Cancer Center, Yale University, New Haven, CT, USA, USA.
  • Maekawa Y; Greenebaum Cancer Center, University of Maryland, Baltimore, MD, USA.
  • Watanabe Y; Fuji Research Park, R&D Division, Kyowa Hakko Kirin Co., Ltd., Shizuoka, Japan.
  • Kashima N; Fuji Research Park, R&D Division, Kyowa Hakko Kirin Co., Ltd., Shizuoka, Japan.
  • Nakashima D; Fuji Research Park, R&D Division, Kyowa Hakko Kirin Co., Ltd., Shizuoka, Japan.
  • Akinaga S; Planning Department, Kyowa Hakko Kirin Pharma Inc., Princeton, NJ, USA.
Cancer Sci ; 107(4): 499-506, 2016 Apr.
Article in En | MEDLINE | ID: mdl-26850678
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Breast Neoplasms / Receptor, Insulin / Receptor, IGF Type 1 / Colonic Neoplasms / Receptor, ErbB-2 / Protein Kinase Inhibitors Type of study: Prognostic_studies Limits: Adult / Aged / Animals / Female / Humans Language: En Journal: Cancer Sci Year: 2016 Document type: Article Affiliation country:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Breast Neoplasms / Receptor, Insulin / Receptor, IGF Type 1 / Colonic Neoplasms / Receptor, ErbB-2 / Protein Kinase Inhibitors Type of study: Prognostic_studies Limits: Adult / Aged / Animals / Female / Humans Language: En Journal: Cancer Sci Year: 2016 Document type: Article Affiliation country: