[Effect of radio frequency discharge plasma on surface properties and biocompatibility of polycaprolactone matrices].
Biomed Khim
; 62(1): 56-63, 2016.
Article
in Ru
| MEDLINE
| ID: mdl-26973188
ABSTRACT
Surface modification of bioresorbable polymer material (polycaprolactone, PCL) with abnormal glow discharge, initiated during radio-frequency magnetron sputtering of a hydroxyapatite target was investigated. Plasma treatment resulted in an increase of surface roughness of PCL, crystallite size, the surface free energy and hydrophilicity. Increased treatment time (30, 60, 150 seconds) provoked the polymer surface saturation with the sputtering target ions (calcium, phosphorus). The assessment of plasma exposure of PCL surface on bone marrow multipotent mesenchymal stromal cells behavior (BM MSCs) has been performed. Modification of the polymer surface with the abnormal glow discharge stimulated adhesion and subsequent proliferation of BM MSCs; thus, maximum values were achieved with the surface treatment for 60 s. This type of plasma modification did not affect cell viability (apoptosis, necrosis). Thus, the surface modification with abnormal glow discharge, initiated during radio-frequency magnetron sputtering of a hydroxyapatite target, appear to be a promising method of surface modification of bioresorbable polymer material (PCL) for tissue engineering.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Polyesters
/
Materials Testing
/
Bone Marrow Cells
/
Plasma Gases
/
Mesenchymal Stem Cells
Limits:
Animals
Language:
Ru
Journal:
Biomed Khim
Year:
2016
Document type:
Article
Affiliation country: