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[1-8-NαC]-Zanriorb A1, a Proapoptotic Orbitide from Leaves of Zanthoxylum riedelianum.
Dos S Beirigo, Pâmela J; Torquato, Heron F V; Dos Santos, Carlos H C; Carvalho, Mário G de; Castro, Rosane N; Paredes-Gamero, Edgar J; de Sousa, Paulo T; Jacinto, Marcos J; da Silva, Virgínia C.
Affiliation
  • Dos S Beirigo PJ; Departamento de Química, Universidade Federal de Mato Grosso , Cuiabá, MT 78060-900, Brazil.
  • Torquato HF; Departamento de Bioquímica, Universidade Federal de São Paulo , São Paulo, SP 04039-032, Brazil.
  • Dos Santos CH; Departamento de Química, Universidade Federal Rural do Rio de Janeiro , Seropédica, RJ 23890-000, Brazil.
  • Carvalho MG; Departamento de Química, Universidade Federal Rural do Rio de Janeiro , Seropédica, RJ 23890-000, Brazil.
  • Castro RN; Departamento de Química, Universidade Federal Rural do Rio de Janeiro , Seropédica, RJ 23890-000, Brazil.
  • Paredes-Gamero EJ; Departamento de Bioquímica, Universidade Federal de São Paulo , São Paulo, SP 04039-032, Brazil.
  • de Sousa PT; Departamento de Química, Universidade Federal de Mato Grosso , Cuiabá, MT 78060-900, Brazil.
  • Jacinto MJ; Departamento de Química, Universidade Federal de Mato Grosso , Cuiabá, MT 78060-900, Brazil.
  • da Silva VC; Departamento de Química, Universidade Federal de Mato Grosso , Cuiabá, MT 78060-900, Brazil.
J Nat Prod ; 79(5): 1454-8, 2016 05 27.
Article in En | MEDLINE | ID: mdl-27082849
ABSTRACT
A new orbitide named [1-8-NαC]-zanriorb A1 (1) was isolated and characterized from the leaves of Zanthoxylum riedelianum using NMR and mass spectrometry. The absolute configuration of the amino acids was determined using Marfey's method on the acid hydrolysates. Compound 1 induced cell death by apoptosis in Jurkat leukemia T cells (IC50 218 nM).
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptides, Cyclic / Apoptosis / Plant Leaves / Zanthoxylum Limits: Humans Country/Region as subject: America do sul / Brasil Language: En Journal: J Nat Prod Year: 2016 Document type: Article Affiliation country:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptides, Cyclic / Apoptosis / Plant Leaves / Zanthoxylum Limits: Humans Country/Region as subject: America do sul / Brasil Language: En Journal: J Nat Prod Year: 2016 Document type: Article Affiliation country: