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Quantitative Analyses of Hepatic OATP-Mediated Interactions Between Statins and Inhibitors Using PBPK Modeling With a Parameter Optimization Method.
Yoshikado, T; Yoshida, K; Kotani, N; Nakada, T; Asaumi, R; Toshimoto, K; Maeda, K; Kusuhara, H; Sugiyama, Y.
Affiliation
  • Yoshikado T; Sugiyama Laboratory, RIKEN Innovation Center, RIKEN, Yokohama, Kanagawa, Japan.
  • Yoshida K; Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan.
  • Kotani N; Clinical Pharmacology Strategy Group, Translational Clinical Research Science & Strategy Dept., Chugai Pharmaceutical Co., Tokyo, Japan.
  • Nakada T; DMPK Research Laboratories Sohyaku, Innovative Research Division, Mitsubishi Tanabe Pharma, Chiba, Japan.
  • Asaumi R; Pharmacokinetic Research Laboratories, Ono Pharmaceutical Co., Ibaraki, Japan.
  • Toshimoto K; Sugiyama Laboratory, RIKEN Innovation Center, RIKEN, Yokohama, Kanagawa, Japan.
  • Maeda K; Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan.
  • Kusuhara H; Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan.
  • Sugiyama Y; Sugiyama Laboratory, RIKEN Innovation Center, RIKEN, Yokohama, Kanagawa, Japan. ychi.sugiyama@riken.jp.
Clin Pharmacol Ther ; 100(5): 513-523, 2016 Nov.
Article in En | MEDLINE | ID: mdl-27170342
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Hydroxymethylglutaryl-CoA Reductase Inhibitors / Organic Anion Transporters / Enzyme Inhibitors / Liver Limits: Humans Language: En Journal: Clin Pharmacol Ther Year: 2016 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Hydroxymethylglutaryl-CoA Reductase Inhibitors / Organic Anion Transporters / Enzyme Inhibitors / Liver Limits: Humans Language: En Journal: Clin Pharmacol Ther Year: 2016 Document type: Article Affiliation country: Country of publication: