Corifollitropin alfa versus recombinant follicle-stimulating hormone: an individual patient data meta-analysis.
Reprod Biomed Online
; 33(1): 56-60, 2016 Jul.
Article
in En
| MEDLINE
| ID: mdl-27178762
ABSTRACT
A meta-analysis was conducted of individual patient data (n = 3292) from three randomized controlled trials of corifollitropin alfa versus rFSH Engage (150 µg corifollitropin alfa n = 756; 200 IU rFSH n = 750), Ensure (100 µg corifollitropin alfa n = 268; 150 IU rFSH n = 128), and Pursue (150 µg corifollitropin alfa n = 694; 300 IU rFSH n = 696). Women with regular menstrual cycles aged 18-36 and body weight >60 kg (Engage) or ≤60 kg (Ensure), or women aged 35-42 years and body weight ≥50 kg (Pursue), received a single injection (100 µg or 150 µg) of corifollitropin alfa (based on body weight and age) or daily rFSH. The difference (corifollitropin alfa minus rFSH) in the number of oocytes retrieved was +1.0 (95% CI 0.5-1.5); vital pregnancy rate -2.2% (95% CI -5.3%-0.9%); ongoing pregnancy rate -1.7% (95% CI -4.7%-1.4%); and live birth rate -2.0% (95% CI -5.0%-1.1%). The odds ratio for overall OHSS was 1.15 (95% CI 0.82-1.61), and for moderate-to-severe OHSS 1.29 (95% CI 0.81-2.05). A single dose of corifollitropin alfa for the first 7 days of ovarian stimulation is a generally well-tolerated and similarly effective treatment compared with daily rFSH.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Ovulation Induction
/
Recombinant Proteins
/
Follicle Stimulating Hormone, Human
/
Follicle Stimulating Hormone
Type of study:
Clinical_trials
/
Etiology_studies
/
Systematic_reviews
Limits:
Adult
/
Female
/
Humans
/
Pregnancy
Language:
En
Journal:
Reprod Biomed Online
Journal subject:
MEDICINA REPRODUTIVA
Year:
2016
Document type:
Article
Affiliation country: