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Use of Pathogen-Specific Antibody Biomarkers to Estimate Waterborne Infections in Population-Based Settings.
Exum, Natalie G; Pisanic, Nora; Granger, Douglas A; Schwab, Kellogg J; Detrick, Barbara; Kosek, Margaret; Egorov, Andrey I; Griffin, Shannon M; Heaney, Christopher D.
Affiliation
  • Exum NG; Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.
  • Pisanic N; Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.
  • Granger DA; Institute for Interdisciplinary Salivary Bioscience Research, University of California Irvine, Irvine, CA, USA.
  • Schwab KJ; Department of Population, Family and Reproductive Health, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.
  • Detrick B; Department of Pediatrics, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
  • Kosek M; Department of Acute and Chronic Care, School of Nursing, Johns Hopkins University, Baltimore, Maryland, USA.
  • Egorov AI; Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.
  • Griffin SM; Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
  • Heaney CD; Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Curr Environ Health Rep ; 3(3): 322-34, 2016 09.
Article in En | MEDLINE | ID: mdl-27352014
ABSTRACT
PURPOSE OF REVIEW This review discusses the utility of pathogen-specific antibody biomarkers for improving estimates of the population burden of waterborne infections, assessing the fraction of infections that can be prevented by specific water treatments, and understanding transmission routes and the natural history and ecology of disease in different populations (including asymptomatic infection rates). RECENT

FINDINGS:

We review recent literature on the application of pathogen-specific antibody response data to estimate incidence and prevalence of acute infections and their utility to assess the contributions of waterborne transmission pathways. Advantages and technical challenges associated with the use of serum versus minimally invasive salivary antibody biomarkers in cross-sectional and prospective surveys are discussed. We highlight recent advances and challenges and outline future directions for research, development, and application of antibody-based and other immunological biomarkers of waterborne infections.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Water Microbiology / Biomarkers / Waterborne Diseases / Antibodies Type of study: Incidence_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Curr Environ Health Rep Year: 2016 Document type: Article Affiliation country:
Fulltext
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Print
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Water Microbiology / Biomarkers / Waterborne Diseases / Antibodies Type of study: Incidence_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Curr Environ Health Rep Year: 2016 Document type: Article Affiliation country: