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Canopy Venom: Proteomic Comparison among New World Arboreal Pit-Viper Venoms.
Debono, Jordan; Cochran, Chip; Kuruppu, Sanjaya; Nouwens, Amanda; Rajapakse, Niwanthi W; Kawasaki, Minami; Wood, Kelly; Dobson, James; Baumann, Kate; Jouiaei, Mahdokht; Jackson, Timothy N W; Koludarov, Ivan; Low, Dolyce; Ali, Syed A; Smith, A Ian; Barnes, Andrew; Fry, Bryan G.
Affiliation
  • Debono J; Venom Evolution Lab, School of Biological Sciences, University of Queensland, St Lucia, QLD 4072, Australia. jordan.debono@uqconnect.edu.au.
  • Cochran C; Department of Earth and Biological Sciences, Loma Linda University, Loma Linda, CA 92350, USA. rcochran@llu.edu.
  • Kuruppu S; Department of Biochemistry & Molecular Biology, Biomedical Discovery Institute, Monash University, Clayton, VIC 3800, Australia. sanjaya.kuruppu@monash.edu.
  • Nouwens A; School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, QLD 4072, Australia. a.nouwens@uq.edu.au.
  • Rajapakse NW; Baker IDI Heart and Diabetes Institute, 75 Commercial Road, Melbourne, Victoria 3004, Australia. niwanthi.rajapakse@bakeridi.edu.au.
  • Kawasaki M; Department of Physiology, Biomedical Discovery Institute, Monash University, Clayton, VIC 3800, Australia. niwanthi.rajapakse@bakeridi.edu.au.
  • Wood K; Aquatic Animal Health, School of Biological Sciences, University of Queensland, St Lucia, QLD 4072 Australia. minami.kawasaki@uqconnect.edu.au.
  • Dobson J; Venom Evolution Lab, School of Biological Sciences, University of Queensland, St Lucia, QLD 4072, Australia. gone2@westnet.com.au.
  • Baumann K; Venom Evolution Lab, School of Biological Sciences, University of Queensland, St Lucia, QLD 4072, Australia. james.dobson@uqconnect.edu.au.
  • Jouiaei M; Venom Evolution Lab, School of Biological Sciences, University of Queensland, St Lucia, QLD 4072, Australia. kate.baumann@uqconnect.edu.au.
  • Jackson TN; Venom Evolution Lab, School of Biological Sciences, University of Queensland, St Lucia, QLD 4072, Australia. mahdokht.jouiaei@gmail.com.
  • Koludarov I; Institute for Molecular Bioscience, University of Queensland, St Lucia, QLD 4072, Australia. mahdokht.jouiaei@gmail.com.
  • Low D; Venom Evolution Lab, School of Biological Sciences, University of Queensland, St Lucia, QLD 4072, Australia. tnwjackson@gmail.com.
  • Ali SA; Institute for Molecular Bioscience, University of Queensland, St Lucia, QLD 4072, Australia. tnwjackson@gmail.com.
  • Smith AI; Venom Evolution Lab, School of Biological Sciences, University of Queensland, St Lucia, QLD 4072, Australia. jcoludar@gmail.com.
  • Barnes A; Institute for Molecular Bioscience, University of Queensland, St Lucia, QLD 4072, Australia. jcoludar@gmail.com.
  • Fry BG; Venom Evolution Lab, School of Biological Sciences, University of Queensland, St Lucia, QLD 4072, Australia. dol_yce@hotmail.com.
Toxins (Basel) ; 8(7)2016 07 08.
Article in En | MEDLINE | ID: mdl-27399777
ABSTRACT
Central and South American pitvipers, belonging to the genera Bothrops and Bothriechis, have independently evolved arboreal tendencies. Little is known regarding the composition and activity of their venoms. In order to close this knowledge gap, venom proteomics and toxin activity of species of Bothriechis, and Bothrops (including Bothriopsis) were investigated through established analytical methods. A combination of proteomics and bioactivity techniques was used to demonstrate a similar diversification of venom composition between large and small species within Bothriechis and Bothriopsis. Increasing our understanding of the evolution of complex venom cocktails may facilitate future biodiscoveries.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Trees / Ecosystem / Bothrops / Evolution, Molecular / Crotalid Venoms / Reptilian Proteins / Proteomics Limits: Animals Language: En Journal: Toxins (Basel) Year: 2016 Document type: Article Affiliation country:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Trees / Ecosystem / Bothrops / Evolution, Molecular / Crotalid Venoms / Reptilian Proteins / Proteomics Limits: Animals Language: En Journal: Toxins (Basel) Year: 2016 Document type: Article Affiliation country: