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A novel high mobility group box 1 neutralizing chimeric antibody attenuates drug-induced liver injury and postinjury inflammation in mice.
Lundbäck, Peter; Lea, Jonathan D; Sowinska, Agnieszka; Ottosson, Lars; Fürst, Camilla Melin; Steen, Johanna; Aulin, Cecilia; Clarke, Joanna I; Kipar, Anja; Klevenvall, Lena; Yang, Huan; Palmblad, Karin; Park, B Kevin; Tracey, Kevin J; Blom, Anna M; Andersson, Ulf; Antoine, Daniel J; Erlandsson Harris, Helena.
Affiliation
  • Lundbäck P; Department of Medicine, Rheumatology Unit, Karolinska Institute, Stockholm, Sweden. peter.lundback@medisin.uio.no.
  • Lea JD; MRC Centre for Drug Safety Science, Department of Molecular & Clinical Pharmacology, Liverpool University, Liverpool, United Kingdom.
  • Sowinska A; Department of Medicine, Rheumatology Unit, Karolinska Institute, Stockholm, Sweden.
  • Ottosson L; Department of Women's and Children's Health, Karolinska Institute, Stockholm, Sweden.
  • Fürst CM; Section of Medical Protein Chemistry, Department of Translational Medicine, Lund University, Malmö, Sweden.
  • Steen J; Department of Medicine, Rheumatology Unit, Karolinska Institute, Stockholm, Sweden.
  • Aulin C; Department of Medicine, Rheumatology Unit, Karolinska Institute, Stockholm, Sweden.
  • Clarke JI; MRC Centre for Drug Safety Science, Department of Molecular & Clinical Pharmacology, Liverpool University, Liverpool, United Kingdom.
  • Kipar A; MRC Centre for Drug Safety Science, Department of Molecular & Clinical Pharmacology, Liverpool University, Liverpool, United Kingdom.
  • Klevenvall L; Department of Women's and Children's Health, Karolinska Institute, Stockholm, Sweden.
  • Yang H; Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, Manhasset, NY, USA.
  • Palmblad K; Department of Women's and Children's Health, Karolinska Institute, Stockholm, Sweden.
  • Park BK; MRC Centre for Drug Safety Science, Department of Molecular & Clinical Pharmacology, Liverpool University, Liverpool, United Kingdom.
  • Tracey KJ; Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, Manhasset, NY, USA.
  • Blom AM; Section of Medical Protein Chemistry, Department of Translational Medicine, Lund University, Malmö, Sweden.
  • Andersson U; Department of Women's and Children's Health, Karolinska Institute, Stockholm, Sweden.
  • Antoine DJ; MRC Centre for Drug Safety Science, Department of Molecular & Clinical Pharmacology, Liverpool University, Liverpool, United Kingdom. D.Antoine@liverpool.ac.uk.
  • Erlandsson Harris H; Department of Medicine, Rheumatology Unit, Karolinska Institute, Stockholm, Sweden. helena.harris@ki.se.
Hepatology ; 64(5): 1699-1710, 2016 11.
Article in En | MEDLINE | ID: mdl-27474782
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: HMGB1 Protein / Chemical and Drug Induced Liver Injury / Antibodies, Neutralizing / Inflammation Type of study: Etiology_studies / Prognostic_studies Limits: Animals Language: En Journal: Hepatology Year: 2016 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: HMGB1 Protein / Chemical and Drug Induced Liver Injury / Antibodies, Neutralizing / Inflammation Type of study: Etiology_studies / Prognostic_studies Limits: Animals Language: En Journal: Hepatology Year: 2016 Document type: Article Affiliation country: Country of publication: