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Design and synthesis of triarylacrylonitrile analogues of tamoxifen with improved binding selectivity to protein kinase C.
Carpenter, Colleen; Sorenson, Roderick J; Jin, Yafei; Klossowski, Szymon; Cierpicki, Tomasz; Gnegy, Margaret; Showalter, Hollis D.
Affiliation
  • Carpenter C; Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109, United States.
  • Sorenson RJ; Department of Medicinal Chemistry, University of Michigan, Ann Arbor, MI 48109, United States; Vahlteich Medicinal Chemistry Core, University of Michigan, Ann Arbor, MI 48109, United States.
  • Jin Y; Department of Medicinal Chemistry, University of Michigan, Ann Arbor, MI 48109, United States; Vahlteich Medicinal Chemistry Core, University of Michigan, Ann Arbor, MI 48109, United States.
  • Klossowski S; Department of Pathology, University of Michigan, Ann Arbor, MI 48109, United States.
  • Cierpicki T; Department of Pathology, University of Michigan, Ann Arbor, MI 48109, United States.
  • Gnegy M; Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109, United States.
  • Showalter HD; Department of Medicinal Chemistry, University of Michigan, Ann Arbor, MI 48109, United States; Vahlteich Medicinal Chemistry Core, University of Michigan, Ann Arbor, MI 48109, United States. Electronic address: showalh@umich.edu.
Bioorg Med Chem ; 24(21): 5495-5504, 2016 11 01.
Article in En | MEDLINE | ID: mdl-27647375
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tamoxifen / Acrylonitrile / Protein Kinase C / Drug Design / Protein Kinase Inhibitors Limits: Humans Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2016 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tamoxifen / Acrylonitrile / Protein Kinase C / Drug Design / Protein Kinase Inhibitors Limits: Humans Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2016 Document type: Article Affiliation country: Country of publication: