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Endogenously produced nonclassical vitamin D hydroxy-metabolites act as "biased" agonists on VDR and inverse agonists on RORα and RORγ.
Slominski, Andrzej T; Kim, Tae-Kang; Hobrath, Judith V; Oak, Allen S W; Tang, Edith K Y; Tieu, Elaine W; Li, Wei; Tuckey, Robert C; Jetten, Anton M.
Affiliation
  • Slominski AT; Department of Dermatology, USA; Comprehensive Cancer Center, Cancer Chemoprevention Program, University of Alabama at Birmingham, USA; Pathology and Laboratory Medicine Service, VA Medical Center, Birmingham, AL, 35249, USA. Electronic address: aslominski@uabmc.edu.
  • Kim TK; Department of Dermatology, USA.
  • Hobrath JV; Drug Discovery Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom.
  • Oak ASW; Department of Dermatology, USA.
  • Tang EKY; School of Chemistry and Biochemistry, University of Western Australia, Crawley, WA, Australia.
  • Tieu EW; School of Chemistry and Biochemistry, University of Western Australia, Crawley, WA, Australia.
  • Li W; Department of Pharmaceutical Sciences University of Tennessee HSC, Memphis, TN 38163, USA.
  • Tuckey RC; School of Chemistry and Biochemistry, University of Western Australia, Crawley, WA, Australia.
  • Jetten AM; Cell Biology Section, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, 27709, USA.
J Steroid Biochem Mol Biol ; 173: 42-56, 2017 10.
Article in En | MEDLINE | ID: mdl-27693422
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Vitamins / Receptors, Calcitriol / Nuclear Receptor Subfamily 1, Group F, Member 1 / Nuclear Receptor Subfamily 1, Group F, Member 3 / Hydroxycholecalciferols Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Steroid Biochem Mol Biol Journal subject: BIOLOGIA MOLECULAR / BIOQUIMICA Year: 2017 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Vitamins / Receptors, Calcitriol / Nuclear Receptor Subfamily 1, Group F, Member 1 / Nuclear Receptor Subfamily 1, Group F, Member 3 / Hydroxycholecalciferols Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Steroid Biochem Mol Biol Journal subject: BIOLOGIA MOLECULAR / BIOQUIMICA Year: 2017 Document type: Article