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JAK-STAT Signaling Jump Starts the Hair Cycle.
Wang, Etienne; Harel, Sivan; Christiano, Angela M.
Affiliation
  • Wang E; Department of Dermatology, Columbia University, New York, New York, USA. Electronic address: ew2445@cumc.columbia.edu.
  • Harel S; Department of Dermatology, Columbia University, New York, New York, USA.
  • Christiano AM; Department of Dermatology, College of Physicians and Surgeons, Columbia University, New York, New York, USA. Electronic address: amc65@cumc.columbia.edu.
J Invest Dermatol ; 136(11): 2131-2132, 2016 11.
Article in En | MEDLINE | ID: mdl-27772548
Legrand et al show that JAK/STAT5 signaling in the dermal papilla is required for anagen onset in the murine hair cycle. Interestingly, others have shown that JAK-inhibition is able to induce telogen-to-anagen transition in wild-type mice. This apparent contradiction highlights the complexity of interactions within the hair follicle, and encourages further discussion on the role of JAK-STAT signaling in the various stem cell niches of the hair follicle.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Gene Expression Regulation / Hair Follicle / STAT5 Transcription Factor / Janus Kinases / Hair Diseases Limits: Animals / Humans Language: En Journal: J Invest Dermatol Year: 2016 Document type: Article Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Gene Expression Regulation / Hair Follicle / STAT5 Transcription Factor / Janus Kinases / Hair Diseases Limits: Animals / Humans Language: En Journal: J Invest Dermatol Year: 2016 Document type: Article Country of publication: