JAK-STAT Signaling Jump Starts the Hair Cycle.
J Invest Dermatol
; 136(11): 2131-2132, 2016 11.
Article
in En
| MEDLINE
| ID: mdl-27772548
Legrand et al show that JAK/STAT5 signaling in the dermal papilla is required for anagen onset in the murine hair cycle. Interestingly, others have shown that JAK-inhibition is able to induce telogen-to-anagen transition in wild-type mice. This apparent contradiction highlights the complexity of interactions within the hair follicle, and encourages further discussion on the role of JAK-STAT signaling in the various stem cell niches of the hair follicle.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Gene Expression Regulation
/
Hair Follicle
/
STAT5 Transcription Factor
/
Janus Kinases
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Hair Diseases
Limits:
Animals
/
Humans
Language:
En
Journal:
J Invest Dermatol
Year:
2016
Document type:
Article
Country of publication: