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A rapid and efficient analytical method for the quantification of a novel anticholinergic compound, R-phencynonate, by stable isotope-dilution LC-MS/MS and its application to bioavailability and dose proportionality studies.
Li, Jinglai; Liao, Sha; Wang, Xiaoying; Liu, Qian; Meng, Fei; Zhang, Wenpeng; Zhang, Tianhong; Yang, Cuiping; Song, Xinyi; Luo, Huan; Wang, Juan; Li, Zheng; Zhong, Bohua; Zhang, Zhenqing.
Affiliation
  • Li J; State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing, People's Republic of China.
  • Liao S; State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing, People's Republic of China.
  • Wang X; State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing, People's Republic of China.
  • Liu Q; State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing, People's Republic of China.
  • Meng F; State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing, People's Republic of China.
  • Zhang W; State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing, People's Republic of China.
  • Zhang T; State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing, People's Republic of China.
  • Yang C; New Drug Safety Evaluation Center, Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing, People's Republic of China.
  • Song X; State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing, People's Republic of China.
  • Luo H; Department of Preventive Medicine, Qinghai University School of Medicine, Xining, People's Republic of China.
  • Wang J; State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing, People's Republic of China.
  • Li Z; State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing, People's Republic of China.
  • Zhong B; State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing, People's Republic of China.
  • Zhang Z; State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing, People's Republic of China.
Biomed Chromatogr ; 31(5)2017 May.
Article in En | MEDLINE | ID: mdl-27790733

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aza Compounds / Chromatography, Liquid / Tandem Mass Spectrometry / Glycolates Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals Language: En Journal: Biomed Chromatogr Year: 2017 Document type: Article

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aza Compounds / Chromatography, Liquid / Tandem Mass Spectrometry / Glycolates Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals Language: En Journal: Biomed Chromatogr Year: 2017 Document type: Article