The effect of interleukin-2 on the blood-brain barrier in the 9L gliosarcoma rat model.
J Neurosurg
; 70(1): 92-6, 1989 Jan.
Article
in En
| MEDLINE
| ID: mdl-2783343
ABSTRACT
Carbon-14-labeled aminoisobutyric acid was used to determine local blood-to-tissue transfer constants in 22 Fischer rats with intracerebral 9L gliosarcomas that received either high-dose parenteral interleukin-2 (IL-2) or a control injection. In tumor and peritumoral tissue, the transfer constants in the IL-2-treated animals (89.6 +/- 14.6 and 35.8 +/- 6.0, respectively, mean +/- standard error of the mean) were larger (p less than 0.05) than in control animals (61.4 +/- 6.4 and 14.6 +/- 2.2, respectively). In contrast, in normal frontal and occipital tissue contralateral to the tumor-bearing hemisphere, there was no significant difference between the transfer constants in IL-2-treated and control animals. Furthermore, treatment of animals with IL-2 excipient caused no change in permeability as compared to animals treated with Hanks' balanced salt solution. Parenteral injection of IL-2 increases blood-brain barrier disruption in tumor-bearing rat brain but does not increase the vascular permeability of normal brain. Methods to prevent this increased tumor vessel permeability are required before parenteral IL-2 can be used safely for the treatment of primary or metastatic brain tumors.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Brain Neoplasms
/
Blood-Brain Barrier
/
Interleukin-2
/
Glioma
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
J Neurosurg
Year:
1989
Document type:
Article