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New Xymedon Analogues for Stimulation of Posttraumatic Regeneration of the Spinal Cord in Rats.
Povysheva, T V; Semenov, V E; Galyametdinova, I V; Reznik, V S; Knni, K S; Kolesnikov, P E; Chelyshev, Yu A.
Affiliation
  • Povysheva TV; Laboratory of Nucleobases Chemistry, A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center of Russian Academy of Sciences, Kazan, Russia. t.povysheva@gmail.com.
  • Semenov VE; Laboratory of Nucleobases Chemistry, A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center of Russian Academy of Sciences, Kazan, Russia.
  • Galyametdinova IV; Laboratory of Nucleobases Chemistry, A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center of Russian Academy of Sciences, Kazan, Russia.
  • Reznik VS; Laboratory of Nucleobases Chemistry, A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center of Russian Academy of Sciences, Kazan, Russia.
  • Knni KS; Department of Histology, Cytology and Embryology, Kazan State Medical University of Ministry of Health of Russian Federation, Kazan, Russia.
  • Kolesnikov PE; Department of Histology, Cytology and Embryology, Kazan State Medical University of Ministry of Health of Russian Federation, Kazan, Russia.
  • Chelyshev YA; Department of Histology, Cytology and Embryology, Kazan State Medical University of Ministry of Health of Russian Federation, Kazan, Russia.
Bull Exp Biol Med ; 162(2): 220-224, 2016 Dec.
Article in En | MEDLINE | ID: mdl-27905041
ABSTRACT
Effect of systemic administration of synthetic pyrimidine derivatives, xymedon and compounds 29D and 34D, was studied in rats with experimental dosed contusion spinal cord injury. Xymedon promoted recovery of motor function after injury. Compounds 29D and 34D more effectively restored the parameters of open-field and Rotarod tests in comparison with xymedon. Compound 29D more effectively than xymedon maintained the number of Olig2+ oligodendrocytes in the corticospinal tract and NG2 cells in all investigated areas of the white matter. In the group treated with compound 34D, the differences in the number of NG2+ cells were revealed only in the anterior funiculi, where the number of these glial cells was 2-fold higher than in the xymedon-treated group. Obtained results suggest that the studied xymedon analogs, compounds 29D and 34D, can exert their therapeutic action through different molecular and cellular pathways.
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Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidines / Spinal Cord / Spinal Cord Injuries / Neuroprotective Agents / Recovery of Function / Nerve Regeneration Language: En Journal: Bull Exp Biol Med Year: 2016 Document type: Article Affiliation country:
Search on Google
Add to My VHL
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PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidines / Spinal Cord / Spinal Cord Injuries / Neuroprotective Agents / Recovery of Function / Nerve Regeneration Language: En Journal: Bull Exp Biol Med Year: 2016 Document type: Article Affiliation country: