Rats can acquire conditional fear of faint light leaking through the acrylic resin used to mount fiber optic cannulas.
Learn Mem
; 23(12): 684-688, 2016 12.
Article
in En
| MEDLINE
| ID: mdl-27918272
ABSTRACT
Rodents are exquisitely sensitive to light and optogenetic behavioral experiments routinely introduce light-delivery materials into experimental situations, which raises the possibility that light could leak and influence behavioral performance. We examined whether rats respond to a faint diffusion of light, termed caplight, which emanated through the translucent dental acrylic resin used to affix deep-brain optical cannulas in place. Although rats did not display significant changes in locomotion or rearing to caplight in a darkened open field, they did acquire conditional fear via caplight-footshock pairings. These findings highlight the potential confounding influence of extraneous light emanating from light-delivery materials during optogenetic analyses.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Acrylic Resins
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Catheters, Indwelling
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Optical Fibers
/
Fear
/
Optogenetics
/
Light
Limits:
Animals
Language:
En
Journal:
Learn Mem
Journal subject:
NEUROLOGIA
Year:
2016
Document type:
Article
Affiliation country: