Efficacy of mitomycin-C and infliximab in reducing adhesionand fibrosis following strabismus surgery.
Turk J Med Sci
; 46(5): 1401-1406, 2016 Nov 17.
Article
in En
| MEDLINE
| ID: mdl-27966305
ABSTRACT
BACKGROUND/AIM:
The present study aimed to investigate the efficacy of mitomycin-C (MMC) and infliximab (INF) in reducing adhesion and fibrosis following strabismus surgery. MATERIALS ANDMETHODS:
Forty eyes of 20 albino rabbits were separated into MMC and INF groups. Right and left eyes of rabbits were assigned to the drug and control groups, respectively. The superior rectus muscle was disinserted, the drug was administered to the surgical area for 5 min in the drug eyes (MMC 0.2 mg/mL or INF 5 mg/mL), and physiological saline was administered to the control eyes. Surgical areas were rinsed with 10 mL of physiological saline. The disinserted muscle was then sutured to the same area using 6.0 Vicryl. The rabbits were sacrificed after 4 weeks for histopathological examination.RESULTS:
Significant reduction was observed in fibrosis in the INF group as compared to the control group (P = 0.005). Although adhesion formation in the drug eyes reduced in the MMC and INF groups as compared to the control group, the difference was not significant (P = 0.280 and P = 0.579, respectively).CONCLUSION:
This study demonstrated the fibrosis-preventing efficacy of IFN; thus, it can be a good option in reducing fibrosis in strabismus surgery.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Strabismus
Limits:
Animals
Language:
En
Journal:
Turk J Med Sci
Year:
2016
Document type:
Article
Affiliation country: