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Evaluation of the Hepatoprotective Effect of L-Ascorbate 1-(2-Hydroxyethyl)-4,6-Dimethyl-1,2-Dihydropyrimidine-2-One Upon Exposure to Carbon Tetrachloride.
Vyshtakalyuk, A B; Nazarov, N G; Zobov, V V; Abdulkhakov, S R; Minnekhanova, O A; Semenov, V E; Galyametdinova, I V; Cherepnev, G V; Reznik, V S.
Affiliation
  • Vyshtakalyuk AB; A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Research Center of the Russian Academy of Sciences, Kazan, Russia. alex.vysh@mail.ru.
  • Nazarov NG; A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Research Center of the Russian Academy of Sciences, Kazan, Russia.
  • Zobov VV; Kazan (Volga Region) Federal University, Kazan, Russia.
  • Abdulkhakov SR; A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Research Center of the Russian Academy of Sciences, Kazan, Russia.
  • Minnekhanova OA; Kazan (Volga Region) Federal University, Kazan, Russia.
  • Semenov VE; Kazan (Volga Region) Federal University, Kazan, Russia.
  • Galyametdinova IV; A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Research Center of the Russian Academy of Sciences, Kazan, Russia.
  • Cherepnev GV; A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Research Center of the Russian Academy of Sciences, Kazan, Russia.
  • Reznik VS; A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Research Center of the Russian Academy of Sciences, Kazan, Russia.
Bull Exp Biol Med ; 162(3): 340-342, 2017 Jan.
Article in En | MEDLINE | ID: mdl-28091907
ABSTRACT
Hepatoprotective properties of a new pyrimidine derivative - L-ascorbate 1-(2-hydroxyethyl)-4,6-dimethyl-1,2-dihydropyrimidine-2-one, synthesized on the basis Xymedon, were assessed in white rats exposed to CCl4. The compound under study administered prior to exposure to CCl4 reduced the deviation of biochemical parameters from reference values and severity of structural and morphological changes in liver, when compared to the control. Hepatoprotective properties of the studied compound were more pronounced than those of Xymedon.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ascorbic Acid / Pyrimidines / Protective Agents / Chemical and Drug Induced Liver Injury / Liver / Antioxidants Limits: Animals Language: En Journal: Bull Exp Biol Med Year: 2017 Document type: Article Affiliation country:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ascorbic Acid / Pyrimidines / Protective Agents / Chemical and Drug Induced Liver Injury / Liver / Antioxidants Limits: Animals Language: En Journal: Bull Exp Biol Med Year: 2017 Document type: Article Affiliation country: