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SMARCA4-inactivating mutations increase sensitivity to Aurora kinase A inhibitor VX-680 in non-small cell lung cancers.
Tagal, Vural; Wei, Shuguang; Zhang, Wei; Brekken, Rolf A; Posner, Bruce A; Peyton, Michael; Girard, Luc; Hwang, TaeHyun; Wheeler, David A; Minna, John D; White, Michael A; Gazdar, Adi F; Roth, Michael G.
Affiliation
  • Tagal V; Department of Biochemistry, UT Southwestern, Dallas, Texas 75390, USA.
  • Wei S; Department of Biochemistry, UT Southwestern, Dallas, Texas 75390, USA.
  • Zhang W; Department of Pathology, UT Southwestern, Dallas, Texas 75390, USA.
  • Brekken RA; Hamon Center for Therapeutic Oncology Research, UT Southwestern, Dallas, Texas 75390, USA.
  • Posner BA; Hamon Center for Therapeutic Oncology Research, UT Southwestern, Dallas, Texas 75390, USA.
  • Peyton M; Department of Pharmacology, UT Southwestern, Dallas, Texas 75390, USA.
  • Girard L; Harold Simmons Comprehensive Cancer Center, UT Southwestern, Dallas, Texas 75390, USA.
  • Hwang T; Department of Biochemistry, UT Southwestern, Dallas, Texas 75390, USA.
  • Wheeler DA; Harold Simmons Comprehensive Cancer Center, UT Southwestern, Dallas, Texas 75390, USA.
  • Minna JD; Hamon Center for Therapeutic Oncology Research, UT Southwestern, Dallas, Texas 75390, USA.
  • White MA; Hamon Center for Therapeutic Oncology Research, UT Southwestern, Dallas, Texas 75390, USA.
  • Gazdar AF; Department of Pharmacology, UT Southwestern, Dallas, Texas 75390, USA.
  • Roth MG; Department of Clinical Sciences, UT Southwestern, Dallas, Texas 75390, USA.
Nat Commun ; 8: 14098, 2017 01 19.
Article in En | MEDLINE | ID: mdl-28102363
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Piperazines / Transcription Factors / Nuclear Proteins / Carcinoma, Non-Small-Cell Lung / DNA Helicases / Aurora Kinase A / Lung Neoplasms Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2017 Document type: Article Affiliation country:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Piperazines / Transcription Factors / Nuclear Proteins / Carcinoma, Non-Small-Cell Lung / DNA Helicases / Aurora Kinase A / Lung Neoplasms Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2017 Document type: Article Affiliation country: