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A somatic-mutational process recurrently duplicates germline susceptibility loci and tissue-specific super-enhancers in breast cancers.
Glodzik, Dominik; Morganella, Sandro; Davies, Helen; Simpson, Peter T; Li, Yilong; Zou, Xueqing; Diez-Perez, Javier; Staaf, Johan; Alexandrov, Ludmil B; Smid, Marcel; Brinkman, Arie B; Rye, Inga Hansine; Russnes, Hege; Raine, Keiran; Purdie, Colin A; Lakhani, Sunil R; Thompson, Alastair M; Birney, Ewan; Stunnenberg, Hendrik G; van de Vijver, Marc J; Martens, John W M; Børresen-Dale, Anne-Lise; Richardson, Andrea L; Kong, Gu; Viari, Alain; Easton, Douglas; Evan, Gerard; Campbell, Peter J; Stratton, Michael R; Nik-Zainal, Serena.
Affiliation
  • Glodzik D; Wellcome Trust Sanger Institute, Cambridge, UK.
  • Morganella S; Wellcome Trust Sanger Institute, Cambridge, UK.
  • Davies H; Wellcome Trust Sanger Institute, Cambridge, UK.
  • Simpson PT; The University of Queensland: UQ Centre for Clinical Research and School of Medicine, Brisbane, Queensland, Australia.
  • Li Y; Wellcome Trust Sanger Institute, Cambridge, UK.
  • Zou X; Wellcome Trust Sanger Institute, Cambridge, UK.
  • Diez-Perez J; Wellcome Trust Sanger Institute, Cambridge, UK.
  • Staaf J; Department of Clinical Sciences Lund, Division of Oncology and Pathology, Lund University, Lund, Sweden.
  • Alexandrov LB; Wellcome Trust Sanger Institute, Cambridge, UK.
  • Smid M; Theoretical Biology and Biophysics (T-6), Los Alamos National Laboratory, Los Alamos, New Mexico, USA.
  • Brinkman AB; Center for Nonlinear Studies, Los Alamos National Laboratory, Los Alamos, New Mexico, USA.
  • Rye IH; Department of Medical Oncology, Erasmus MC Cancer Institute and Cancer Genomics Netherlands, Erasmus University Medical Center, Rotterdam, the Netherlands.
  • Russnes H; Department of Molecular Biology, Faculties of Science and Medicine, Radboud University, Nijmegen, the Netherlands.
  • Raine K; Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital, Norwegian Radiumhospital, Oslo, Norway.
  • Purdie CA; K.G. Jebsen Centre for Breast Cancer Research, Institute for Clinical Medicine, University of Oslo, Oslo, Norway.
  • Lakhani SR; Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital, Norwegian Radiumhospital, Oslo, Norway.
  • Thompson AM; K.G. Jebsen Centre for Breast Cancer Research, Institute for Clinical Medicine, University of Oslo, Oslo, Norway.
  • Birney E; Wellcome Trust Sanger Institute, Cambridge, UK.
  • Stunnenberg HG; Department of Pathology, Ninewells Hospital &Medical School, Dundee, UK.
  • van de Vijver MJ; The University of Queensland: UQ Centre for Clinical Research and School of Medicine, Brisbane, Queensland, Australia.
  • Martens JW; Pathology Queensland, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.
  • Børresen-Dale AL; Department of Pathology, Ninewells Hospital &Medical School, Dundee, UK.
  • Richardson AL; Department of Breast Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  • Kong G; European Molecular Biology Laboratory, European Bioinformatics Institute, Cambridgeshire, UK.
  • Viari A; Department of Medical Oncology, Erasmus MC Cancer Institute and Cancer Genomics Netherlands, Erasmus University Medical Center, Rotterdam, the Netherlands.
  • Easton D; Department of Pathology, Academic Medical Center, Amsterdam, the Netherlands.
  • Evan G; Department of Medical Oncology, Erasmus MC Cancer Institute and Cancer Genomics Netherlands, Erasmus University Medical Center, Rotterdam, the Netherlands.
  • Campbell PJ; Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital, Norwegian Radiumhospital, Oslo, Norway.
  • Stratton MR; K.G. Jebsen Centre for Breast Cancer Research, Institute for Clinical Medicine, University of Oslo, Oslo, Norway.
  • Nik-Zainal S; Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Nat Genet ; 49(3): 341-348, 2017 Mar.
Article in En | MEDLINE | ID: mdl-28112740
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Breast Neoplasms / Regulatory Sequences, Nucleic Acid / Genetic Loci / Mutation Limits: Female / Humans Language: En Journal: Nat Genet Journal subject: GENETICA MEDICA Year: 2017 Document type: Article Affiliation country: Country of publication:
Fulltext
Add to My VHL
Print
XML
PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Breast Neoplasms / Regulatory Sequences, Nucleic Acid / Genetic Loci / Mutation Limits: Female / Humans Language: En Journal: Nat Genet Journal subject: GENETICA MEDICA Year: 2017 Document type: Article Affiliation country: Country of publication: