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Pharmacologic ATM but not ATR kinase inhibition abrogates p21-dependent G1 arrest and promotes gastrointestinal syndrome after total body irradiation.
Vendetti, Frank P; Leibowitz, Brian J; Barnes, Jennifer; Schamus, Sandy; Kiesel, Brian F; Abberbock, Shira; Conrads, Thomas; Clump, David Andy; Cadogan, Elaine; O'Connor, Mark J; Yu, Jian; Beumer, Jan H; Bakkenist, Christopher J.
Affiliation
  • Vendetti FP; Department of Radiation Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  • Leibowitz BJ; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  • Barnes J; DNA Damage Response Biology Area, Oncology IMED, AstraZeneca, Cambridge, UK.
  • Schamus S; Department of Radiation Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  • Kiesel BF; Cancer Therapeutics Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA.
  • Abberbock S; Department of Biostatistics, University of Pittsburgh School of Public Health, Pittsburgh, PA, USA.
  • Conrads T; Inova Schar Cancer Institute, Inova Center for Personalized Health, Falls Church, VA, USA.
  • Clump DA; Department of Radiation Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  • Cadogan E; DNA Damage Response Biology Area, Oncology IMED, AstraZeneca, Cambridge, UK.
  • O'Connor MJ; DNA Damage Response Biology Area, Oncology IMED, AstraZeneca, Cambridge, UK.
  • Yu J; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  • Beumer JH; Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, USA.
  • Bakkenist CJ; Department of Radiation Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Sci Rep ; 7: 41892, 2017 02 01.
Article in En | MEDLINE | ID: mdl-28145510
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Radiation Injuries, Experimental / Radiation-Protective Agents / G1 Phase / Protein Kinase Inhibitors / Acute Radiation Syndrome / Gastrointestinal Diseases / Intestinal Mucosa Limits: Animals Language: En Journal: Sci Rep Year: 2017 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Radiation Injuries, Experimental / Radiation-Protective Agents / G1 Phase / Protein Kinase Inhibitors / Acute Radiation Syndrome / Gastrointestinal Diseases / Intestinal Mucosa Limits: Animals Language: En Journal: Sci Rep Year: 2017 Document type: Article Affiliation country: Country of publication: