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Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases.
Harris, Philip A; Berger, Scott B; Jeong, Jae U; Nagilla, Rakesh; Bandyopadhyay, Deepak; Campobasso, Nino; Capriotti, Carol A; Cox, Julie A; Dare, Lauren; Dong, Xiaoyang; Eidam, Patrick M; Finger, Joshua N; Hoffman, Sandra J; Kang, James; Kasparcova, Viera; King, Bryan W; Lehr, Ruth; Lan, Yunfeng; Leister, Lara K; Lich, John D; MacDonald, Thomas T; Miller, Nathan A; Ouellette, Michael T; Pao, Christina S; Rahman, Attiq; Reilly, Michael A; Rendina, Alan R; Rivera, Elizabeth J; Schaeffer, Michelle C; Sehon, Clark A; Singhaus, Robert R; Sun, Helen H; Swift, Barbara A; Totoritis, Rachel D; Vossenkämper, Anna; Ward, Paris; Wisnoski, David D; Zhang, Daohua; Marquis, Robert W; Gough, Peter J; Bertin, John.
Affiliation
  • MacDonald TT; Centre for Immunobiology, Blizard Institute, Barts, and The London School of Medicine and Dentistry, Queen Mary University of London , E1 2AD London, U.K.
  • Vossenkämper A; Centre for Immunobiology, Blizard Institute, Barts, and The London School of Medicine and Dentistry, Queen Mary University of London , E1 2AD London, U.K.
J Med Chem ; 60(4): 1247-1261, 2017 02 23.
Article in En | MEDLINE | ID: mdl-28151659
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Colitis, Ulcerative / Protein Kinase Inhibitors / Receptor-Interacting Protein Serine-Threonine Kinases / Inflammation / Anti-Inflammatory Agents Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2017 Document type: Article Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Colitis, Ulcerative / Protein Kinase Inhibitors / Receptor-Interacting Protein Serine-Threonine Kinases / Inflammation / Anti-Inflammatory Agents Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2017 Document type: Article Country of publication: