Expression of Marek's Disease Virus Oncoprotein Meq During Infection in the Natural Host.
Virology
; 503: 103-113, 2017 03.
Article
in En
| MEDLINE
| ID: mdl-28160668
ABSTRACT
Gallid herpesvirus 2 (Marek's disease virus, MDV) causes lymphoproliferative Marek's disease (MD), and is unique among alphaherpesviruses as the viral genome encodes an oncoprotein, Meq. To elucidate the temporal relationship between Meq expression and the development of MD lymphomas in infected chickens, we generated a virulent recombinant MDV that expresses GFP simultaneously with Meq. By using this virus, we monitored the dynamics of Meq expression in vivo throughout the course of infection. In peripheral blood mononuclear cells, the percentage of Meq-expressing cells dramatically increased in the early latent phase but decreased thereafter. Furthermore, we discovered evidences that indicate some of the infected lymphocytes did not express Meq during the latent phase of MDV pathogenesis. These findings provide the first insight into the temporal relationship between Meq expression and MD progression, and new clues to refine the current MD pathogenesis model.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Poultry Diseases
/
CD4-Positive T-Lymphocytes
/
Oncogene Proteins, Viral
/
Marek Disease
/
Herpesvirus 2, Gallid
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Virology
Year:
2017
Document type:
Article
Affiliation country: