Targeting IKK and NF-κB for Therapy.
Adv Protein Chem Struct Biol
; 107: 77-115, 2017.
Article
in En
| MEDLINE
| ID: mdl-28215229
ABSTRACT
In addition to regulating immune responses, the NF-κB family of transcription factors also promotes cellular proliferation and survival. NF-κB and its activating kinase, IKK, have become appealing therapeutic targets because of their critical roles in the progression of many diseases including chronic inflammation and cancer. Here, we discuss the conditions that lead to pathway activation, the effects of constitutive activation, and some of the strategies used to inhibit NF-κB signaling.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
NF-kappa B
/
I-kappa B Kinase
Limits:
Humans
Language:
En
Journal:
Adv Protein Chem Struct Biol
Journal subject:
BIOLOGIA
/
BIOQUIMICA
Year:
2017
Document type:
Article
Affiliation country: