Your browser doesn't support javascript.
loading
Copper-catalyzed Direct 2-Arylation of Benzoxazoles and Benzoimidazoles with Aryl Bromides and Cytotoxicity of Products.
Jia, Nan-Nan; Tian, Xin-Chuan; Qu, Xiao-Xia; Chen, Xing-Xiu; Cao, Ya-Nan; Yao, Yun-Xin; Gao, Feng; Zhou, Xian-Li.
Affiliation
  • Jia NN; School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, P. R. China.
  • Tian XC; Department of Chinese Traditional Herbal, Agronomy College, Sichuan Agriculture University, Chengdu 611130, P. R. China.
  • Qu XX; Department of Chinese Traditional Herbal, Agronomy College, Sichuan Agriculture University, Chengdu 611130, P. R. China.
  • Chen XX; Department of Chinese Traditional Herbal, Agronomy College, Sichuan Agriculture University, Chengdu 611130, P. R. China.
  • Cao YN; Department of Chinese Traditional Herbal, Agronomy College, Sichuan Agriculture University, Chengdu 611130, P. R. China.
  • Yao YX; Department of Chinese Traditional Herbal, Agronomy College, Sichuan Agriculture University, Chengdu 611130, P. R. China.
  • Gao F; Department of Chinese Traditional Herbal, Agronomy College, Sichuan Agriculture University, Chengdu 611130, P. R. China.
  • Zhou XL; School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, P. R. China.
Sci Rep ; 7: 43758, 2017 03 03.
Article in En | MEDLINE | ID: mdl-28256577
ABSTRACT
An efficient copper-catalyzed direct 2-arylation of benzoxazoles and benzoimidazoles with aryl bromides is presented. The CuI/PPh3-based catalyst promotes the installation of various aryl and heteroaryl groups through a C-H activation process in good to excellent yields. The cytotoxicity of obtained 2-aryl benzoxazoles (benzoimidazoles) was also evaluated and 1-methyl-2-(naphthalen-1-yl)benzoimidazole showed potential cytotoxicity.
Subject(s)
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzene / Benzoxazoles / Bromides / Copper / Imidazoles Limits: Humans Language: En Journal: Sci Rep Year: 2017 Document type: Article
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzene / Benzoxazoles / Bromides / Copper / Imidazoles Limits: Humans Language: En Journal: Sci Rep Year: 2017 Document type: Article