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T cell costimulatory receptor CD28 is a primary target for PD-1-mediated inhibition.
Hui, Enfu; Cheung, Jeanne; Zhu, Jing; Su, Xiaolei; Taylor, Marcus J; Wallweber, Heidi A; Sasmal, Dibyendu K; Huang, Jun; Kim, Jeong M; Mellman, Ira; Vale, Ronald D.
Affiliation
  • Hui E; Department of Cellular and Molecular Pharmacology and the Howard Hughes Medical Institute, University of California, San Francisco, CA 94158, USA.
  • Cheung J; Department of Cancer Immunology, Genentech, South San Francisco, CA 94080, USA.
  • Zhu J; Department of Cancer Immunology, Genentech, South San Francisco, CA 94080, USA.
  • Su X; Department of Cellular and Molecular Pharmacology and the Howard Hughes Medical Institute, University of California, San Francisco, CA 94158, USA.
  • Taylor MJ; Department of Cellular and Molecular Pharmacology and the Howard Hughes Medical Institute, University of California, San Francisco, CA 94158, USA.
  • Wallweber HA; Department of Cancer Immunology, Genentech, South San Francisco, CA 94080, USA.
  • Sasmal DK; Institute for Molecular Engineering, University of Chicago, IL 60637, USA.
  • Huang J; Institute for Molecular Engineering, University of Chicago, IL 60637, USA.
  • Kim JM; Department of Cancer Immunology, Genentech, South San Francisco, CA 94080, USA.
  • Mellman I; Department of Cancer Immunology, Genentech, South San Francisco, CA 94080, USA. mellman.ira@gene.com ron.vale@ucsf.edu.
  • Vale RD; Department of Cellular and Molecular Pharmacology and the Howard Hughes Medical Institute, University of California, San Francisco, CA 94158, USA. mellman.ira@gene.com ron.vale@ucsf.edu.
Science ; 355(6332): 1428-1433, 2017 03 31.
Article in En | MEDLINE | ID: mdl-28280247
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: T-Lymphocytes / CD28 Antigens / B7-H1 Antigen / Programmed Cell Death 1 Receptor / Neoplasms Limits: Animals / Humans Language: En Journal: Science Year: 2017 Document type: Article Affiliation country:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: T-Lymphocytes / CD28 Antigens / B7-H1 Antigen / Programmed Cell Death 1 Receptor / Neoplasms Limits: Animals / Humans Language: En Journal: Science Year: 2017 Document type: Article Affiliation country: