Multifunctional nanoparticle composites: progress in the use of soft and hard nanoparticles for drug delivery and imaging.
Wiley Interdiscip Rev Nanomed Nanobiotechnol
; 9(6)2017 11.
Article
in En
| MEDLINE
| ID: mdl-28299903
ABSTRACT
With continued advancements in nanoparticle (NP) synthesis and in the interfacing of NPs with biological systems has come the exponential growth in the use of NPs for therapeutic drug delivery and imaging applications. In recent years, the advent of NP multifunctionality-the ability to perform multiple, disparate functions on a single NP platform-has garnered much excitement for the potential realization of highly functional NP-mediated drug delivery for use in the clinical setting. This Overview will survey the current state of the art (reports published within the last 5 years) of multifunctional NPs for therapeutic drug delivery, imaging or a combination thereof. We provide extensive examples of both soft (micelles, liposomes, polymeric NPs) and hard (noble metals, quantum dots, metal oxides) NP formulations that have been used for multimodal drug delivery and imaging. The criteria for inclusion, herein, is that there must be at least two therapeutic drug cargos or imaging agents or a combination of the two. We next offer an assessment of the cytotoxicity of therapeutic NP constructs in biological systems. We then conclude with a forward-looking perspective on how we expect this field to develop in the coming years. WIREs Nanomed Nanobiotechnol 2017, 9e1466. doi 10.1002/wnan.1466 For further resources related to this article, please visit the WIREs website.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Diagnostic Imaging
/
Drug Delivery Systems
/
Nanoparticles
Type of study:
Diagnostic_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
Wiley Interdiscip Rev Nanomed Nanobiotechnol
Year:
2017
Document type:
Article
Affiliation country: