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XPLN is modulated by HDAC inhibitors and negatively regulates SPARC expression by targeting mTORC2 in human lung fibroblasts.
Kamio, Koichiro; Azuma, Arata; Usuki, Jiro; Matsuda, Kuniko; Inomata, Minoru; Nishijima, Nobuhiko; Itakura, Shioto; Hayashi, Hiroki; Kashiwada, Takeru; Kokuho, Nariaki; Atsumi, Kenichiro; Yamaguchi, Tomoyoshi; Fujita, Kazue; Saito, Yoshinobu; Abe, Shinji; Kubota, Kaoru; Gemma, Akihiko.
Affiliation
  • Kamio K; Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan.
  • Azuma A; Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan. Electronic address: a-azuma@nms.ac.jp.
  • Usuki J; Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan.
  • Matsuda K; Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan.
  • Inomata M; Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan.
  • Nishijima N; Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan.
  • Itakura S; Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan.
  • Hayashi H; Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan.
  • Kashiwada T; Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan.
  • Kokuho N; Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan.
  • Atsumi K; Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan.
  • Yamaguchi T; Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan.
  • Fujita K; Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan.
  • Saito Y; Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan.
  • Abe S; Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan.
  • Kubota K; Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan.
  • Gemma A; Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan.
Pulm Pharmacol Ther ; 44: 61-69, 2017 06.
Article in En | MEDLINE | ID: mdl-28315487
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Idiopathic Pulmonary Fibrosis / Histone Deacetylase Inhibitors / Fibroblasts / Rho Guanine Nucleotide Exchange Factors Limits: Humans Language: En Journal: Pulm Pharmacol Ther Journal subject: FARMACOLOGIA Year: 2017 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Idiopathic Pulmonary Fibrosis / Histone Deacetylase Inhibitors / Fibroblasts / Rho Guanine Nucleotide Exchange Factors Limits: Humans Language: En Journal: Pulm Pharmacol Ther Journal subject: FARMACOLOGIA Year: 2017 Document type: Article Affiliation country: Country of publication: