Biologic Therapies for Immunoglobulin E-mediated Food Allergy and Eosinophilic Esophagitis.
Immunol Allergy Clin North Am
; 37(2): 369-396, 2017 05.
Article
in En
| MEDLINE
| ID: mdl-28366483
ABSTRACT
Immunoglobulin (Ig) E-mediated food allergy and eosinophilic esophagitis (EoE) are chronic, allergen-mediated disorders characterized by an aberrant TH2 immune response. The development and investigation of biologics for the treatment of IgE-mediated food allergy and eosinophilic esophagitis have provided further insight into the pathophysiology and management of these disorders. This article provides an overview of biologic therapies that are being investigated or have potential as treatments for IgE-mediated food allergy and eosinophilic esophagitis. Identification of EoE phenotypes that are responsive to biologics and investigation of biologics combined with other therapies may help elucidate a role for biologics in EoE.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Biological Therapy
/
Immunoglobulin E
/
Eosinophilic Esophagitis
/
Food Hypersensitivity
Limits:
Humans
Language:
En
Journal:
Immunol Allergy Clin North Am
Journal subject:
ALERGIA E IMUNOLOGIA
Year:
2017
Document type:
Article