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Joining Forces: Bmi1 Inhibition and Cisplatin Curb Squamous Carcinogenesis.
Brown, Jessie A; Schober, Markus.
Affiliation
  • Brown JA; The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, NY 10016, USA.
  • Schober M; The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, NY 10016, USA. Electronic address: markus.schober@nyumc.org.
Cell Stem Cell ; 20(5): 575-577, 2017 05 04.
Article in En | MEDLINE | ID: mdl-28475877
ABSTRACT
Head and neck squamous cell carcinomas (HNSCCs) are refractory to therapeutic interventions. Chen et al. (2017) show that mouse and human HNSCCs and their metastases depend on Bmi1-expressing cancer stem cells and AP1 signaling and that simultaneously inhibiting Bmi1 or AP1, combined with Cisplatin, reduces tumor growth effectively in preclinical models.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carcinoma, Squamous Cell / Cisplatin / Polycomb Repressive Complex 1 / Head and Neck Neoplasms Limits: Animals / Humans Language: En Journal: Cell Stem Cell Year: 2017 Document type: Article Affiliation country:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carcinoma, Squamous Cell / Cisplatin / Polycomb Repressive Complex 1 / Head and Neck Neoplasms Limits: Animals / Humans Language: En Journal: Cell Stem Cell Year: 2017 Document type: Article Affiliation country: