Severe Hypernatremic Dehydration and Lower Limb Gangrene in an Infant Exposed to Lamotrigine, Aripiprazole, and Sertraline in Breast Milk.
Breastfeed Med
; 12(6): 377-380, 2017.
Article
in En
| MEDLINE
| ID: mdl-28481632
ABSTRACT
BACKGROUND:
Hypernatremic dehydration is well described in exclusively breastfed neonates, although life-threatening complications are rarely reported. MATERIALS ANDMETHODS:
The present article describes a case of severe hypernatremic dehydration in a previously healthy term neonate. Other published cases of severe complications of hypernatremic dehydration are discussed.RESULTS:
The exclusively breastfed neonate described had severe hypernatremic dehydration because of inadequate milk intake, with disseminated intravascular coagulation and right lower limb gangrene that required amputation of all five toes and surgical debridement of the metatarsals. The usual etiology of hypernatremic dehydration in this age group is insufficient breast milk intake. Here, the infant's mother was treated for bipolar disorder with lamotrigine 250 mg orally once daily, aripiprazole 15 mg orally once daily, and sertraline 100 mg orally once daily.CONCLUSIONS:
Awareness of these complications should prompt close follow-up of the infant with poor weight gain. The role of maternal medication as a risk factor for hypernatremic dehydration among exclusively breastfed infants needs to be further explored.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Breast Feeding
/
Lower Extremity
/
Dehydration
/
Gangrene
/
Hypernatremia
/
Milk, Human
/
Antidepressive Agents
Type of study:
Risk_factors_studies
Limits:
Adult
/
Female
/
Humans
/
Male
/
Newborn
Language:
En
Journal:
Breastfeed Med
Journal subject:
CIENCIAS DA NUTRICAO
Year:
2017
Document type:
Article
Affiliation country: