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Cytoprotective effect of neuropeptides on cancer stem cells: vasoactive intestinal peptide-induced antiapoptotic signaling.
Sastry, Konduru S; Chouchane, Aouatef Ismail; Wang, Ena; Kulik, George; Marincola, Francesco M; Chouchane, Lotfi.
Affiliation
  • Sastry KS; Laboratory of Genetic Medicine and Immunology, Weill Cornell Medicine-Qatar, Education City-Qatar Foundation, Doha 24144, Qatar.
  • Chouchane AI; Division of Translational Medicine, Sidra Medical and Research Center, Doha 26999, Qatar.
  • Wang E; Division of Translational Medicine, Sidra Medical and Research Center, Doha 26999, Qatar.
  • Kulik G; Division of Translational Medicine, Sidra Medical and Research Center, Doha 26999, Qatar.
  • Marincola FM; Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, NC, USA.
  • Chouchane L; College of Science, Alfaisal University, Riyadh 11533, Saudi Arabia.
Cell Death Dis ; 8(6): e2844, 2017 06 01.
Article in En | MEDLINE | ID: mdl-28569785
Subject(s)
Apoptosis/drug effects; Gene Expression Regulation, Neoplastic; Neoplastic Stem Cells/drug effects; Vasoactive Intestinal Peptide/pharmacology; bcl-Associated Death Protein/genetics; Antineoplastic Agents/pharmacology; Apoptosis/genetics; Breast Neoplasms/genetics; Breast Neoplasms/metabolism; Breast Neoplasms/pathology; Cell Line, Tumor; Cyclic AMP-Dependent Protein Kinases/antagonists & inhibitors; Cyclic AMP-Dependent Protein Kinases/genetics; Cyclic AMP-Dependent Protein Kinases/metabolism; Female; Humans; Male; Mitogen-Activated Protein Kinases/antagonists & inhibitors; Mitogen-Activated Protein Kinases/genetics; Mitogen-Activated Protein Kinases/metabolism; Neoplastic Stem Cells/metabolism; Neoplastic Stem Cells/pathology; Niacinamide/analogs & derivatives; Niacinamide/antagonists & inhibitors; Niacinamide/pharmacology; Phenylurea Compounds/antagonists & inhibitors; Phenylurea Compounds/pharmacology; Phosphorylation/drug effects; Prostatic Neoplasms/genetics; Prostatic Neoplasms/metabolism; Prostatic Neoplasms/pathology; RNA, Small Interfering/genetics; RNA, Small Interfering/metabolism; Receptors, Vasoactive Intestinal Peptide/genetics; Receptors, Vasoactive Intestinal Peptide/metabolism; Signal Transduction; Sorafenib; Spheroids, Cellular/drug effects; Spheroids, Cellular/metabolism; Spheroids, Cellular/pathology; bcl-Associated Death Protein/antagonists & inhibitors; bcl-Associated Death Protein/metabolism; ras Proteins/antagonists & inhibitors; ras Proteins/genetics; ras Proteins/metabolism
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Neoplastic Stem Cells / Vasoactive Intestinal Peptide / Gene Expression Regulation, Neoplastic / Apoptosis / Bcl-Associated Death Protein Type of study: Prognostic_studies Language: En Journal: Cell Death Dis Year: 2017 Document type: Article Affiliation country:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Neoplastic Stem Cells / Vasoactive Intestinal Peptide / Gene Expression Regulation, Neoplastic / Apoptosis / Bcl-Associated Death Protein Type of study: Prognostic_studies Language: En Journal: Cell Death Dis Year: 2017 Document type: Article Affiliation country: