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GCH1 plays a role in the high-altitude adaptation of Tibetans.
Guo, Yong-Bo; He, Yao-Xi; Cui, Chao-Ying; Ouzhu, Luobu; Baima, Kangzhuo; Duoji, Zhuoma; Deji, Quzong; Bian, Ba; Peng, Yi; Bai, Cai-Juan; Gongga, Lanzi; Pan, Yong-Yue; Qu, la; Kang, Min; Ciren, Yangji; Baima, Yangji; Guo, Wei; Yang, la; Zhang, Hui; Zhang, Xiao-Ming; Zheng, Wang-Shan; Xu, Shu-Hua; Chen, Hua; Zhao, Sheng-Guo; Cai, Yuan; Liu, Shi-Ming; Wu, Tian-Yi; Qi, Xue-Bin; Su, Bing.
Affiliation
  • Guo YB; College of Animal Science and Technology, Gansu Agricultural University, Lanzhou Gansu 730070, China; State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming Yunnan 650223, China.
  • He YX; State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming Yunnan 650223, China; High Altitude Medical Research Center, School of Medicine, Tibetan University, Lhasa Tibet 850000, China.
  • Cui CY; High Altitude Medical Research Center, School of Medicine, Tibetan University, Lhasa Tibet 850000, China.
  • Ouzhu L; High Altitude Medical Research Center, School of Medicine, Tibetan University, Lhasa Tibet 850000, China.
  • Baima K; High Altitude Medical Research Center, School of Medicine, Tibetan University, Lhasa Tibet 850000, China.
  • Duoji Z; High Altitude Medical Research Center, School of Medicine, Tibetan University, Lhasa Tibet 850000, China.
  • Deji Q; High Altitude Medical Research Center, School of Medicine, Tibetan University, Lhasa Tibet 850000, China.
  • Bian B; High Altitude Medical Research Center, School of Medicine, Tibetan University, Lhasa Tibet 850000, China.
  • Peng Y; State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming Yunnan 650223, China.
  • Bai CJ; High Altitude Medical Research Center, School of Medicine, Tibetan University, Lhasa Tibet 850000, China.
  • Gongga L; High Altitude Medical Research Center, School of Medicine, Tibetan University, Lhasa Tibet 850000, China.
  • Pan YY; High Altitude Medical Research Center, School of Medicine, Tibetan University, Lhasa Tibet 850000, China.
  • Kang M; High Altitude Medical Research Center, School of Medicine, Tibetan University, Lhasa Tibet 850000, China.
  • Ciren Y; High Altitude Medical Research Center, School of Medicine, Tibetan University, Lhasa Tibet 850000, China.
  • Baima Y; High Altitude Medical Research Center, School of Medicine, Tibetan University, Lhasa Tibet 850000, China.
  • Guo W; High Altitude Medical Research Center, School of Medicine, Tibetan University, Lhasa Tibet 850000, China.
  • Yang; State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming Yunnan 650223, China.
  • Zhang H; State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming Yunnan 650223, China.
  • Zhang XM; State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming Yunnan 650223, China.
  • Zheng WS; College of Animal Science and Technology, Gansu Agricultural University, Lanzhou Gansu 730070, China; State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming Yunnan 650223, China.
  • Xu SH; Chinese Academy of Sciences Key Laboratory of Computational Biology, Max Planck Independent Research Group on Population Genomics, CAS-MPG Partner Institute for Computational Biology(PICB), Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China; School of Li
  • Chen H; Center for Computational Genomics, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China.
  • Zhao SG; College of Animal Science and Technology, Gansu Agricultural University, Lanzhou Gansu 730070, China.
  • Cai Y; College of Animal Science and Technology, Gansu Agricultural University, Lanzhou Gansu 730070, China.
  • Liu SM; National Key Laboratory of High Altitude Medicine, High Altitude Medical Research Institute, Xining Qinghai 810012, China.
  • Wu TY; National Key Laboratory of High Altitude Medicine, High Altitude Medical Research Institute, Xining Qinghai 810012, China.
  • Qi XB; State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming Yunnan 650223, China. qixuebin@mail.kiz.ac.cn.
  • Su B; State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming Yunnan 650223, China. sub@mail.kiz.ac.cn.
Zool Res ; 38(3): 155-162, 2017 May 18.
Article in En | MEDLINE | ID: mdl-28585439
ABSTRACT
Tibetans are well adapted to high-altitude hypoxia. Previous genome-wide scans have reported many candidate genes for this adaptation, but only a few have been studied. Here we report on a hypoxia gene ( GCH1, GTP-cyclohydrolase I), involved in maintaining nitric oxide synthetase (NOS) function and normal blood pressure, that harbors many potentially adaptive variants in Tibetans. We resequenced an 80.8 kb fragment covering the entire gene region of GCH1 in 50 unrelated Tibetans. Combined with previously published data, we demonstrated many GCH1 variants showing deep divergence between highlander Tibetans and lowlander Han Chinese. Neutrality tests confirmed a signal of positive Darwinian selection on GCH1 in Tibetans. Moreover, association analysis indicated that the Tibetan version of GCH1 was significantly associated with multiple physiological traits in Tibetans, including blood nitric oxide concentration, blood oxygen saturation, and hemoglobin concentration. Taken together, we propose that GCH1 plays a role in the genetic adaptation of Tibetans to high altitude hypoxia.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Adaptation, Physiological / Ethnicity / Gene Expression Regulation, Enzymologic / Altitude / GTP Cyclohydrolase Limits: Adult / Female / Humans / Male Country/Region as subject: Asia Language: En Journal: Zool Res Year: 2017 Document type: Article Affiliation country:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Adaptation, Physiological / Ethnicity / Gene Expression Regulation, Enzymologic / Altitude / GTP Cyclohydrolase Limits: Adult / Female / Humans / Male Country/Region as subject: Asia Language: En Journal: Zool Res Year: 2017 Document type: Article Affiliation country: